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Regioselective alkylation of 1,2,4-triazole using ionic liquids under microwave conditions

Regioselective alkylation of 1,2,4-triazole using ionic liquids under microwave conditions Abstract 1-Substituted 1,2,4-triazole derivatives present in a large number of compounds and display a variety of bioactivities such as antibiotic, anti-inflammatory, anti-diabetic, antipsychotic, and anticancer. A regioselective protocol has been developed for the alkylation of 1,2,4- triazole using mild conditions. The 1-alkyl-1,2,4-triazole derivatives were synthesized under microwave conditions using potassium carbonate as a base and ionic liquid (hexylpyridinium bromide) as a solvent. The products were obtained in excellent yield, and the base-ionic liquid combination was recycled for a number of times. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Green Processing and Synthesis de Gruyter

Regioselective alkylation of 1,2,4-triazole using ionic liquids under microwave conditions

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Publisher
de Gruyter
Copyright
Copyright © 2016 by the
ISSN
2191-9542
eISSN
2191-9550
DOI
10.1515/gps-2015-0138
Publisher site
See Article on Publisher Site

Abstract

Abstract 1-Substituted 1,2,4-triazole derivatives present in a large number of compounds and display a variety of bioactivities such as antibiotic, anti-inflammatory, anti-diabetic, antipsychotic, and anticancer. A regioselective protocol has been developed for the alkylation of 1,2,4- triazole using mild conditions. The 1-alkyl-1,2,4-triazole derivatives were synthesized under microwave conditions using potassium carbonate as a base and ionic liquid (hexylpyridinium bromide) as a solvent. The products were obtained in excellent yield, and the base-ionic liquid combination was recycled for a number of times.

Journal

Green Processing and Synthesisde Gruyter

Published: Jun 1, 2016

References