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Introduction In 1989 a System of reference measurement procedures was introduced in the Federal Republic of Germany for external quality assessment of clinical chemical testing. Reference methods now provide the basis for the evaluation of participänts' resülts in collaborative surveys. This System has its legal basis in the guidelines of the Bundesärztekanimer (Federal Medical Association) (1), which refer back to the calibration act. It is now mandatory for clinical chemical laboratories to participate in this quality assurance System, and laboratories which do not fulfil the requirements for a certain clinical chegiical analyte will run into trouble with public health insurance. Because öf these restrictive regulations and their consequences for all the laboratories, those who orgänize the collaborative surveys take on a high level of responsibility when they set up reference method values. Since about 1970, pur laboratory has been developing reference measurement procedures on the basis of the methodolpgical principle of isotope dilution mass spectrometry. Twelve different quantities are now regJ ularly measured in various control sera for internal and external quality assessment. In addition to some clinically interesting hormones and the nitrogen-containing metabolites, creatinine and uric acid, the list of analytes also includes the two lipids, total
Clinical Chemistry and Laboratory Medicine – de Gruyter
Published: Jan 1, 1991
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