Krieglsteiner et al: Prenatal prediction of RDS J. Perinat. Med. 4 (1976) 261 Prenatal prediction of respiratory distress syndrome Measurement of surface properties and Lecithin/Sphingomyelin ratio in human amniotic fluid P. Krieglsteiner, R. Schneider, H. Kopeke, W. Tolle, J. Johannigmann, G. Blümel Department of Experimental Surgery, Department of Obstetrics and Gynecology, and Department of Anesthesiology of the "Technische Universität München'' fhe postnatal changes of the lung in the neonatal respiratory distress syndrome (RDS) resemble in their pathological appearance  to a large extent those seen in adult shock lung [6, 23,27,38]. In addition to neurological  and morphological  immaturity, RDS is primarily caused by a lack of surface active substances . The various constituents of surfactant, such äs protein, mucopolysaccharides, electrolytes and phospholipids form a complex biological system  the sum of which ensures alveolar stability . Phospholipids are considered to be most effective fraction [14, 15, 16, 18]. They enter the amniotic fluid andthus are available fordiagnosticprocedures which form the basis for all conventional assays for pulmonary maturity [summarized in 2, 40,. 50]. Among these methods the determination of the L/S ratio according to GLUCK  is the most widely used [3, 4, 9, 10, 11,
Journal of Perinatal Medicine – de Gruyter
Published: Jan 1, 1976
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