Prenatal prediction of respiratory distress syndrome. Measurement of surface properties and Lecithin/Sphingomyelin ratio in human amniotic fluid

Prenatal prediction of respiratory distress syndrome. Measurement of surface properties and... Krieglsteiner et al: Prenatal prediction of RDS J. Perinat. Med. 4 (1976) 261 Prenatal prediction of respiratory distress syndrome Measurement of surface properties and Lecithin/Sphingomyelin ratio in human amniotic fluid P. Krieglsteiner, R. Schneider, H. Kopeke, W. Tolle, J. Johannigmann, G. Blümel Department of Experimental Surgery, Department of Obstetrics and Gynecology, and Department of Anesthesiology of the "Technische Universität München'' fhe postnatal changes of the lung in the neonatal respiratory distress syndrome (RDS) resemble in their pathological appearance [52] to a large extent those seen in adult shock lung [6, 23,27,38]. In addition to neurological [22] and morphological [54] immaturity, RDS is primarily caused by a lack of surface active substances [43]. The various constituents of surfactant, such äs protein, mucopolysaccharides, electrolytes and phospholipids form a complex biological system [53] the sum of which ensures alveolar stability [30]. Phospholipids are considered to be most effective fraction [14, 15, 16, 18]. They enter the amniotic fluid andthus are available fordiagnosticprocedures which form the basis for all conventional assays for pulmonary maturity [summarized in 2, 40,. 50]. Among these methods the determination of the L/S ratio according to GLUCK [17] is the most widely used [3, 4, 9, 10, 11, http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Perinatal Medicine de Gruyter

Prenatal prediction of respiratory distress syndrome. Measurement of surface properties and Lecithin/Sphingomyelin ratio in human amniotic fluid

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Publisher
de Gruyter
Copyright
Copyright © 2009 Walter de Gruyter
ISSN
0300-5577
eISSN
1619-3997
DOI
10.1515/jpme.1976.4.4.261
Publisher site
See Article on Publisher Site

Abstract

Krieglsteiner et al: Prenatal prediction of RDS J. Perinat. Med. 4 (1976) 261 Prenatal prediction of respiratory distress syndrome Measurement of surface properties and Lecithin/Sphingomyelin ratio in human amniotic fluid P. Krieglsteiner, R. Schneider, H. Kopeke, W. Tolle, J. Johannigmann, G. Blümel Department of Experimental Surgery, Department of Obstetrics and Gynecology, and Department of Anesthesiology of the "Technische Universität München'' fhe postnatal changes of the lung in the neonatal respiratory distress syndrome (RDS) resemble in their pathological appearance [52] to a large extent those seen in adult shock lung [6, 23,27,38]. In addition to neurological [22] and morphological [54] immaturity, RDS is primarily caused by a lack of surface active substances [43]. The various constituents of surfactant, such äs protein, mucopolysaccharides, electrolytes and phospholipids form a complex biological system [53] the sum of which ensures alveolar stability [30]. Phospholipids are considered to be most effective fraction [14, 15, 16, 18]. They enter the amniotic fluid andthus are available fordiagnosticprocedures which form the basis for all conventional assays for pulmonary maturity [summarized in 2, 40,. 50]. Among these methods the determination of the L/S ratio according to GLUCK [17] is the most widely used [3, 4, 9, 10, 11,

Journal

Journal of Perinatal Medicinede Gruyter

Published: Jan 1, 1976

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