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Pregnancy-related changes of carnitine and acylcarnitine concentrations of plasma and erythrocytes

Pregnancy-related changes of carnitine and acylcarnitine concentrations of plasma and erythrocytes Schoderbeck et al, L-carnitine changes in pregnancy J. Perinat. Med. 23 (1995) 477-485 Martina Schoderbeck1, Brunhilde Auer1, Elisabeth Legenstein1, Heidrun Genger2, Paul Sevelda2, Heinrich Salzer2, Richard März1, and Alfred Lohninger1 Department of Medical Chemistry, Department of Obstetrics and Gynecology, University of Vienna, Medical School, Vienna, Austria 1 Introduction L-Carnitine serves two major biochemical functions. It is essential for the transport of long chain fatty acids into the mitochondrial matrix and it is important as a reversible sink for acyl residues and the generation of free coenzyme A [5]. L-Carnitine is mainly localized in myocardial and skeletal muscles, which depend upon the oxidation of fatty acids as their major source of energy. These tissues derive their carnitive via the blood since carnitine is either synthesized in the liver and kidney, or supplied from external sources [5]. Plasma carnitine levels on delivery are decreased to about half of the concentrations seen in nonpregnant women [3, 8, 11, 27, 33]. Similar low levels are only found in patients with carnitine deficiency [16]. Whole blood carnitine is divided between plasma and blood cells, representing two different pools which are influenced by different factors [1, 6, 7, 13, 25]. The erythrocyte levels of http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Perinatal Medicine de Gruyter

Pregnancy-related changes of carnitine and acylcarnitine concentrations of plasma and erythrocytes

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Publisher
de Gruyter
Copyright
Copyright © 2009 Walter de Gruyter
ISSN
0300-5577
eISSN
1619-3997
DOI
10.1515/jpme.1995.23.6.477
Publisher site
See Article on Publisher Site

Abstract

Schoderbeck et al, L-carnitine changes in pregnancy J. Perinat. Med. 23 (1995) 477-485 Martina Schoderbeck1, Brunhilde Auer1, Elisabeth Legenstein1, Heidrun Genger2, Paul Sevelda2, Heinrich Salzer2, Richard März1, and Alfred Lohninger1 Department of Medical Chemistry, Department of Obstetrics and Gynecology, University of Vienna, Medical School, Vienna, Austria 1 Introduction L-Carnitine serves two major biochemical functions. It is essential for the transport of long chain fatty acids into the mitochondrial matrix and it is important as a reversible sink for acyl residues and the generation of free coenzyme A [5]. L-Carnitine is mainly localized in myocardial and skeletal muscles, which depend upon the oxidation of fatty acids as their major source of energy. These tissues derive their carnitive via the blood since carnitine is either synthesized in the liver and kidney, or supplied from external sources [5]. Plasma carnitine levels on delivery are decreased to about half of the concentrations seen in nonpregnant women [3, 8, 11, 27, 33]. Similar low levels are only found in patients with carnitine deficiency [16]. Whole blood carnitine is divided between plasma and blood cells, representing two different pools which are influenced by different factors [1, 6, 7, 13, 25]. The erythrocyte levels of

Journal

Journal of Perinatal Medicine – de Gruyter

Published: Jan 1, 1995

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