Potentials of Mangifera indica in the treatment of depressive-anxiety disorders: possible mechanisms of action

Potentials of Mangifera indica in the treatment of depressive-anxiety disorders: possible... Abstract Background : Mangifera indica (Anacardiaceae) is an important herb in the traditional African and Ayurvedic medicines. The stem barks are used in the treatment of hypertension, insomnia, tumour, depression, rheumatism and as a tonic. This study was carried out to investigate antidepressant- and anxiolytic-like effect of the hydroethanol stem bark extract of M. indica (HeMI) in mice. Methods : HeMI (12.5–100 mg/kg, p.o.) was administered 1 h before subjecting the animal to the forced swim test (FST), tail suspension test (TST) and elevated plus maze tests (EPM). Results : HeMI (12.5–100 mg/kg, p.o.) treatment produced significant reduction in immobility time (F(6.56)=8.35, p<0.001), (F(6,56)=7.55, p<0.001) in the FST and TST, respectively. Moreover, co-administration of sub-therapeutic doses of imipramine or fluoxetine with HeMI (3.125 mg/kg) elicited significant reduction in time spent immobile in the FST. However, pretreatment of mice with parachlorophenylalanine, metergoline, yohimbine or sulpiride abolished the antidepressant-like effect elicited by HeMI. In the EPM, HeMI produced significant (F(5,42)=8.91, p<0.001) increase in open arms exploration by 75.55 % and this effect was blocked by pretreatment of mice with flumazenil or metergoline. Conclusions : Findings from this study showed antidepressant-like effect of M. indica through interaction with 5-HT 2 receptor, α 2 -adrenoceptor and dopamine D 2 -receptors. Also, an anxiolytic-like effect through its affinity for 5-HT 2 and benzodiazepine receptors. Hence, M. indica could be a potential phytotherapeutic agent in the treatment of mixed anxiety-depressive illness. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Complementary and Integrative Medicine de Gruyter

Potentials of Mangifera indica in the treatment of depressive-anxiety disorders: possible mechanisms of action

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Publisher
de Gruyter
Copyright
Copyright © 2016 by the
ISSN
2194-6329
eISSN
1553-3840
DOI
10.1515/jcim-2015-0047
pmid
27276531
Publisher site
See Article on Publisher Site

Abstract

Abstract Background : Mangifera indica (Anacardiaceae) is an important herb in the traditional African and Ayurvedic medicines. The stem barks are used in the treatment of hypertension, insomnia, tumour, depression, rheumatism and as a tonic. This study was carried out to investigate antidepressant- and anxiolytic-like effect of the hydroethanol stem bark extract of M. indica (HeMI) in mice. Methods : HeMI (12.5–100 mg/kg, p.o.) was administered 1 h before subjecting the animal to the forced swim test (FST), tail suspension test (TST) and elevated plus maze tests (EPM). Results : HeMI (12.5–100 mg/kg, p.o.) treatment produced significant reduction in immobility time (F(6.56)=8.35, p<0.001), (F(6,56)=7.55, p<0.001) in the FST and TST, respectively. Moreover, co-administration of sub-therapeutic doses of imipramine or fluoxetine with HeMI (3.125 mg/kg) elicited significant reduction in time spent immobile in the FST. However, pretreatment of mice with parachlorophenylalanine, metergoline, yohimbine or sulpiride abolished the antidepressant-like effect elicited by HeMI. In the EPM, HeMI produced significant (F(5,42)=8.91, p<0.001) increase in open arms exploration by 75.55 % and this effect was blocked by pretreatment of mice with flumazenil or metergoline. Conclusions : Findings from this study showed antidepressant-like effect of M. indica through interaction with 5-HT 2 receptor, α 2 -adrenoceptor and dopamine D 2 -receptors. Also, an anxiolytic-like effect through its affinity for 5-HT 2 and benzodiazepine receptors. Hence, M. indica could be a potential phytotherapeutic agent in the treatment of mixed anxiety-depressive illness.

Journal

Journal of Complementary and Integrative Medicinede Gruyter

Published: Sep 1, 2016

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