Anne-Marie Le Bon and Marie-Helene Siess Unite Mixte de Recherche de Toxicologic Alimentaire, Institut National de la Recherche Agronomique, 17 rue Sully, BP 86510, 21065 Dijon Cedex, France CONTENTS Summary 1. Introduction 2. Active constituents of vegetables 3. Epidemiological studies 4. Experimental studies of cancer prevention in animal models 5. Modulation of mutagenicity and genotoxicity 5. Mechanisms of the anticarcinogenic and antigenotoxic effects 6. Conclusion References Â©Freund Publishing House Ltd., 2000 Vol. 17, No. 1-4, 2000 Organosulfur Compounds from SUMMARY vegetables and their associated organosulfur constituents are extensively studied for their chemopreventive potential against cancer. This article overviews their anticarcinogenic and antigenotoxic properties. Epidemiological studies (mostly case-control studies) provide strong evidence that vegetable consumption reduces the incidence of gastric and colon cancer while the association between vegetable consumption and other cancers is less convincing. Furthermore, many experimental studies have demonstrated that organosulfur compounds and extracts have inhibitory effects on carcinogenesis in animals. These inhibitory effects are supported by many diverse mechanisms, including inhibition of carcinogen formation, modulation of carcinogen metabolism, inhibition of mutagenesis and genotoxicity, inhibition of cell proliferation and increase of apoptosis, inhibition of angiogenesis, and immune system enhancement. Before such constituents or extracts can be used
Drug Metabolism and Drug Interactions – de Gruyter
Published: Dec 1, 2000
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