On the Degree of Platelet, Coagulation and Fibrinolysis Activation after Cerebral Infarction and Cerebral Haemorrhage and the Clinical Outcome

On the Degree of Platelet, Coagulation and Fibrinolysis Activation after Cerebral Infarction and... van Wersch and Franke: Haemostaseological quantities after cerebral insult Eur. J. Clin. Chem. Clin. Biochem. Vol.31, 1993, pp. 575-578 © 1993 Waiter de Gruyter & Co. Berlin · New York By y. W. J. van Wersch' and C. L· Franke2 Haematological Laboratory Department of Neurology De Wever Hospital, Heerlen, The Netherlands (Received March 5/June 22, 1993) Summary: Thrombocytic, haemostatic and fibrinolytic quantities were investigated in 47 patients with cerebral infarction and 34 patients with cerebral haemorrhage. Sixteen of the infarction patients and ten patients of the haemorrhage group were on acetylsalicylic acid medication. Of the remaining 55 patients without acetylsalicylic medication 21/31 = 67.7% of the patients in the infarction group and 9/24 = 37.5% of the patients in the bleeding group had unphysiologically enhanced ADP-induced platelet aggregation. With regard to the coagulation and fibrinolysis markers no significant differences were found between the two groups. In both groups, coagulation activity markers (fibrin monomer and thrombin-antithrombin III), as well as Ddimers were significantly higher than in controls in a high proportion of cases. In 5/47 of the infarction patients and in 3/34 of the haemorrhage patients the fibrin monomer levels were elevated to such an extent, that it can http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Clinical Chemistry and Laboratory Medicine de Gruyter

On the Degree of Platelet, Coagulation and Fibrinolysis Activation after Cerebral Infarction and Cerebral Haemorrhage and the Clinical Outcome

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Publisher
de Gruyter
Copyright
Copyright © 2009 Walter de Gruyter
ISSN
1434-6621
eISSN
1437-4331
DOI
10.1515/cclm.1993.31.9.575
Publisher site
See Article on Publisher Site

Abstract

van Wersch and Franke: Haemostaseological quantities after cerebral insult Eur. J. Clin. Chem. Clin. Biochem. Vol.31, 1993, pp. 575-578 © 1993 Waiter de Gruyter & Co. Berlin · New York By y. W. J. van Wersch' and C. L· Franke2 Haematological Laboratory Department of Neurology De Wever Hospital, Heerlen, The Netherlands (Received March 5/June 22, 1993) Summary: Thrombocytic, haemostatic and fibrinolytic quantities were investigated in 47 patients with cerebral infarction and 34 patients with cerebral haemorrhage. Sixteen of the infarction patients and ten patients of the haemorrhage group were on acetylsalicylic acid medication. Of the remaining 55 patients without acetylsalicylic medication 21/31 = 67.7% of the patients in the infarction group and 9/24 = 37.5% of the patients in the bleeding group had unphysiologically enhanced ADP-induced platelet aggregation. With regard to the coagulation and fibrinolysis markers no significant differences were found between the two groups. In both groups, coagulation activity markers (fibrin monomer and thrombin-antithrombin III), as well as Ddimers were significantly higher than in controls in a high proportion of cases. In 5/47 of the infarction patients and in 3/34 of the haemorrhage patients the fibrin monomer levels were elevated to such an extent, that it can

Journal

Clinical Chemistry and Laboratory Medicinede Gruyter

Published: Jan 1, 1993

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