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Non-Enzymatic Activities of Proteases: From Scepticism to Reality

Non-Enzymatic Activities of Proteases: From Scepticism to Reality Biol. Chem., Vol. 383, pp. 1 ­ 4, January 2002 · Copyright © by Walter de Gruyter · Berlin · New York Guest Editorial It has been with great pleasure that the guest editors accepted the proposal of one of the executive editors of Biological Chemistry, Hans Fritz, to put together a highlight issue of the journal, devoted to the content of the First Chianti Meeting on Proteases, entitled "Non-proteolytic roles of proteinases: novel functions for old enzymes", which was held on April 27-May 1, 2001 in the Certosa di Pontignano, in the very heart of Tuscany, Italy. The first hints for non-enzymatic activities of proteases began in the '80s, when structural and sequence analyses revealed that a number of proteases (mainly those implicated in blood coagulation and fibrinolysis) (Patthy et al., 1984, 1985) had evolved by assembly from nonprotease modules. Although a non-protease modular structure has been identified in all main families of proteases, the bulk of evidence for non-protease roles has been obtained in the proteases of the fibrinolytic system (extensively reviewed by Mignatti and Rifkin, 2000), mainly due to the observation that the non-protease modules of these proteases are able to interact with cellsurface molecules http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Biological Chemistry de Gruyter

Non-Enzymatic Activities of Proteases: From Scepticism to Reality

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Publisher
de Gruyter
Copyright
Copyright © 2002 by the
ISSN
1431-6730
DOI
10.1515/BC.2002.001
pmid
11928804
Publisher site
See Article on Publisher Site

Abstract

Biol. Chem., Vol. 383, pp. 1 ­ 4, January 2002 · Copyright © by Walter de Gruyter · Berlin · New York Guest Editorial It has been with great pleasure that the guest editors accepted the proposal of one of the executive editors of Biological Chemistry, Hans Fritz, to put together a highlight issue of the journal, devoted to the content of the First Chianti Meeting on Proteases, entitled "Non-proteolytic roles of proteinases: novel functions for old enzymes", which was held on April 27-May 1, 2001 in the Certosa di Pontignano, in the very heart of Tuscany, Italy. The first hints for non-enzymatic activities of proteases began in the '80s, when structural and sequence analyses revealed that a number of proteases (mainly those implicated in blood coagulation and fibrinolysis) (Patthy et al., 1984, 1985) had evolved by assembly from nonprotease modules. Although a non-protease modular structure has been identified in all main families of proteases, the bulk of evidence for non-protease roles has been obtained in the proteases of the fibrinolytic system (extensively reviewed by Mignatti and Rifkin, 2000), mainly due to the observation that the non-protease modules of these proteases are able to interact with cellsurface molecules

Journal

Biological Chemistryde Gruyter

Published: Jan 23, 2002

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