Hoppe-Seyler's Z. Physiol. Chem. Bd. 357, S. 1699 -1705, Dezember 1976 Neuraminic Acid Derivatives Newly Discovered in Humans: N-Acetyl-9-O-L-lactoylneuraminic Acid, N,9-O-Diacetylneuraminic Acid and 7V-Acetyl-2,3-dehydro-2-deoxyneuramimc Acid* Johan HAVERKAMP, Roland SCHAUER, Margret WEMBER Institut für Physiologische Chemie, Arbeitsgruppe für Zellchemie, Ruhr-Universität Bochum Jean-Pierre FARRIAUX Centre Hospitalier Regional de Lilie, Service de Genetique et Maladies Hereditaires du Metabolisme de l'Enfant Johannis P. KAMERLING, Cornells VERSLUIS and Johannes F.G. VLIEGENTHART Organisch Chemisch Laboratorium der Rijks-Universiteit te Utrecht (Received 17 September 1976) Summary: The free and glycosidically bound acylneuraminic acids from human serum and saliva and the free acylneuraminic acids from human urine have been characterized by thinlayer chromatography and gas-liquid chromatography/mass spectrometry. Acylneuraminic acid mixtures obtained from serum and saliva contain mainly TV-acetylneuraminic acid and^V-acetyl-9-OL-lactoylneuraminic acid, whereas small amounts of 7Y,9-O-diacetylneuraminic acid are also present. No free JV,O-diacylneuraminic acids could be detected in the urine samples. None of the investi- gated fluids contained JV-glycoloylneuraminic acid. The unsaturated 7Vr-acetyl-2,3-dehydro-2-deoxyneuraminic acid is usually a component of the free acylneuraminic acid fractions of serum, saliva and urine. The body fluids of a patient with sialuria contain the same O-acylated and unsaturated W-acetylneuraminic acid derivatives as mentioned above, but the total amounts of free acylneuraminic acids
hoppe-seyler's zeitschrift für physiologische chemie – de Gruyter
Published: Jan 1, 1976
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