Access the full text.
Sign up today, get DeepDyve free for 14 days.
V. Pratt, McLeod Hl, W. Rubinstein, Scott Sa, Dean Lc, Kattman Bl, Malheiro Aj (2012)
Methylenetetrahydrofolate Reductase Deficiency -- Medical Genetics Summaries
T. Deloughery, A. Evans, A. Sadeghi, J. McWilliams, W. Henner, L. Taylor, R. Press (1996)
Common mutation in methylenetetrahydrofolate reductase. Correlation with homocysteine metabolism and late-onset vascular disease.Circulation, 94 12
R. Malina (1983)
Menarche in athletes: a synthesis and hypothesis.Annals of human biology, 10 1
Drug Metab Pers Ther, 32
Xingmin Wang, Jinjian Fu, Qianxi Li, Dingyuan Zeng (2016)
Geographical and Ethnic Distributions of the MTHFR C677T, A1298C and MTRR A66G Gene Polymorphisms in Chinese Populations: A Meta-AnalysisPLoS ONE, 11
P. Jacques, A. Bostom, Roger Williams, R. Ellison, J. Eckfeldt, I. Rosenberg, J. Selhub, R. Rozen (1996)
Relation between folate status, a common mutation in methylenetetrahydrofolate reductase, and plasma homocysteine concentrations.Circulation, 93 1
The National Alliance for Thrombosis and Thrombophilia web - site
R. Jarjour, S. Ammar, Rami Majdalawi (2017)
Frequency of three prothrombotic polymorphisms among Syrian population: factor V G1691A, prothrombin G20210A and methylenetetrahydrofolate reductase C677TAnnals of Human Biology, 44
M. Ayala-Rivera, J. Renta, I. García, L. Garcia, A. Vega, P. Santiago-Borrero, C. Cadilla (1999)
Prevalence of common mutations of the MTHFR gene in a Puerto Rican populationGenetics in Medicine, 1
Raul Morales-Borges (2014)
Prevalence of MTHFR C677T and A1298C Mutations and Thrombophilia in Puerto RicoJournal of Blood Disorders and Transfusion, 2014
N. Marini, Jennifer Gin, J. Ziegle, K. Keho, D. Ginzinger, Dennis Gilbert, J. Rine (2008)
The prevalence of folate-remedial MTHFR enzyme variants in humansProceedings of the National Academy of Sciences, 105
Karla Claudio‐Campos, Carmelo Orengo-Mercado, Jessicca Renta, M. Peguero, Ricardo García, Gabriel Hernández, S. Corey, C. Cadilla, J. Duconge (2015)
Pharmacogenetics of healthy volunteers in Puerto RicoDrug Metabolism and Personalized Therapy, 30
L. Bailey, J. Gregory (1999)
Polymorphisms of methylenetetrahydrofolate reductase and other enzymes: metabolic significance, risks and impact on folate requirement.The Journal of nutrition, 129 5
S. Hickey, C. Curry, H. Toriello (2013)
ACMG Practice Guideline: lack of evidence for MTHFR polymorphism testingGenetics in Medicine, 15
Siaw-Cheok Liew, E. Gupta (2015)
Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism: epidemiology, metabolism and the associated diseases.European journal of medical genetics, 58 1
F. Álvarez-Nava, R. Ortiz, A. Rojas, A. Revol, I. Martfnez, S. Martinez, M. Soto, L. Borias, H. Barrera (1999)
Molecular analysis of SRY gene in patients with mixed gonadal dysgenesisGenetics in Medicine, 1
L. Dean (2016)
Methylenetetrahydrofolate Reductase Deficiency
Patricia McAndrew, John Brandt, Dennis Pearl, Thomas Prior (1996)
The incidence of the gene for thermolabile methylene tetrahydrofolate reductase in African Americans.Thrombosis research, 83 2
A. Perez, V. D’Almeida, N. Vergani, A. Oliveira, F. Lima, D. Brunoni (2003)
Methylenetetrahydrofolate reductase (MTHFR): incidence of mutations C677T and A1298C in Brazilian population and its correlation with plasma homocysteine levels in spina bifidaAmerican Journal of Medical Genetics Part A, 119A
E. Varga, A. Sturm, C. Misita, S. Moll (2005)
Cardiology patient pages. Homocysteine and MTHFR mutations: relation to thrombosis and coronary artery disease.Circulation, 111 19
E. Varga, A. Sturm, C. Misita, S. Moll (2005)
Homocysteine and MTHFR Mutations Relation to Thrombosis and Coronary Artery DiseaseCirculation, 111
Francisco Jiménez-Ramírez, Liza Castro, Clarymar Ortiz, J. Concepción, Jessicca Renta, Raul Morales-Borges, J. Miranda-Massari, J. Duconge (2017)
Role of treatment-modifying MTHFR677C>T and 1298A>C polymorphisms in metformin-treated Puerto Rican patients with type-2 diabetes mellitus and peripheral neuropathyDrug Metabolism and Personalized Therapy, 32
AbstractMethylenetetrahydrofolate reductase (MTHFR) mutations have been linked to many diseases. Evidence has been provided to prove that we need to perform pharmacogenetic studies regarding the prevalence of MTHFR mutations and diseases, risks, and the impact on folate requirement in general, but little has been published about Puerto Ricans. A multi center cross-sectional retrospective review study or a prospective pharmacogenetic study of valid genotypes and phenotypes of MTHFR mutations within the different populations of Puerto Ricans and Hispanics are recommended, because differences within them and within the general population are expected.
Drug Metabolism and Drug Interactions – de Gruyter
Published: Sep 26, 2017
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.