K.KJP. Hartmann Pediatric Endocrinology, Univemtaets-Kinderklinik Frankfurt/Main, Germany The development of new techniques especially in the field of molecular biology and protein chemistry has led to a more profound understanding of the impact of different hormones. In addition to the hormones themselves, their specific receptors and binding proteins have become a focus of interest surrounding recent research into human growth disorders. The mutation of the genes for growth hormone and growth hormone receptors as well as the regulation of the gene expression of these proteins has gained importance in the diagnosis of certain severe growth disorders. Growth hormone (GH), human chorionicsomatomammotropin (hCS) and prolactin (PRL) are related molecules. The amino acid sequence of GH and PRL are 35% identical whereas the sequences of GH and hCS are 85% identical. The genes for GH and hCS are located on chromosome 17, the gene for PRL is located on chromosome 6. A gene cluster for GH and hCS, composed of 2 GH and 2 hCS genes plus 1 hCS-similar gene, has been described on chromosome 17 /1-3/. The first GH gene (GH-1) encodes for the circulating, biologically active GH; in contrast, the GH-protein of GH-2 is 13 amino acid residues smaller
Journal of Pediatric Endocrinology and Metabolism – de Gruyter
Published: Jan 1, 1993
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.
Read from thousands of the leading scholarly journals from SpringerNature, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera