Abstract A simple, environmentally friendly, one-pot method for the synthesis of 4-aminoquinazolines using microwave irradiation has been developed. Structures of derivatives 3 , 4 , and 5 were confirmed by single-crystal X-ray diffraction. The in vitro cytotoxicity of each compound was investigated using an MTT assay with A549 and HepG2 cell lines to calculate half-maximal inhibitory concentrations.
Green Processing and Synthesis – de Gruyter
Published: Jun 1, 2016