Low dose aspirin in pregnancy: a clinical and biochemical study of effects on the newborn

Low dose aspirin in pregnancy: a clinical and biochemical study of effects on the newborn Introduction Curriculum vitae Dr ADRIANA VALCAMONICO was born in Brescia (Italy) in 1962. She attained her degree in medicine at the University of Brescia in 1987. After clinical training at the University Hospital in Brescia, she specialized in Obstetrics and Gynecology in 1991. Since 1988 she has been a member of the Study Group of Hypertension in Pregnancy of the University of Brescia. She is a researcher in the field of perinatal medicine, with particular interest in hypertensive disease in pregnancy and fetal ultrasound. Pregnancy induced hypertension (PIH) is one of the most important diseases in pregnancy. An imbalance between prostacyclin (vasodilator and antiaggregating agent) and thromboxane (vasoconstrictive and aggregating factor) is considered one of the major pathogenetic mechanisms of this disease. Low dose Aspirin (LDA) (50 --100 mg/day) has been used in clinical trials for the prevention of PIH and IUGR with encouraging results [1, 7, 10, 11]. The clinical benefit of LDA is thought to derive from inhibition of platelet thromboxane production [2]. As Aspirin crosses the placenta, one of the major problems of its use is the effect on the fetus and the newborn. In fact, several Authors have reported neonatal intracranial hemorrhage and other http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Perinatal Medicine de Gruyter

Low dose aspirin in pregnancy: a clinical and biochemical study of effects on the newborn

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Publisher
de Gruyter
Copyright
Copyright © 2009 Walter de Gruyter
ISSN
0300-5577
eISSN
1619-3997
DOI
10.1515/jpme.1993.21.3.235
Publisher site
See Article on Publisher Site

Abstract

Introduction Curriculum vitae Dr ADRIANA VALCAMONICO was born in Brescia (Italy) in 1962. She attained her degree in medicine at the University of Brescia in 1987. After clinical training at the University Hospital in Brescia, she specialized in Obstetrics and Gynecology in 1991. Since 1988 she has been a member of the Study Group of Hypertension in Pregnancy of the University of Brescia. She is a researcher in the field of perinatal medicine, with particular interest in hypertensive disease in pregnancy and fetal ultrasound. Pregnancy induced hypertension (PIH) is one of the most important diseases in pregnancy. An imbalance between prostacyclin (vasodilator and antiaggregating agent) and thromboxane (vasoconstrictive and aggregating factor) is considered one of the major pathogenetic mechanisms of this disease. Low dose Aspirin (LDA) (50 --100 mg/day) has been used in clinical trials for the prevention of PIH and IUGR with encouraging results [1, 7, 10, 11]. The clinical benefit of LDA is thought to derive from inhibition of platelet thromboxane production [2]. As Aspirin crosses the placenta, one of the major problems of its use is the effect on the fetus and the newborn. In fact, several Authors have reported neonatal intracranial hemorrhage and other

Journal

Journal of Perinatal Medicinede Gruyter

Published: Jan 1, 1993

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