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Linde Type A and nano magnetite/NaA zeolites: cytotoxicity and doxorubicin loading efficiency

Linde Type A and nano magnetite/NaA zeolites: cytotoxicity and doxorubicin loading efficiency AbstractDifferent cation-exchanged (K+, Na+ & Ca2+) nano-zeolites withi magnetite nanocomposites were synthesized and their suitability for drug loading was studied. Nanocomposites with different Fe3O4 contents were synthesized by adding magnetic Fe3O4 nanoparticles to the zeolite crystallization solution. The zeolite and its nanocomposites had high surface areas and enough adsorption capacity to load and release sufficient amounts of the chemotherapeutic doxorubicin. None or the zeolites or nanocomposites showed toxicity to SKBr3 or MCF-7 cancer cells. However, DOX@zeolite inhibits cell growth more than the non-encapsulated drug. Thus zeolites and their magnetite nanocomposites show potential as biocompatible medical devices. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Open Chemistry de Gruyter

Linde Type A and nano magnetite/NaA zeolites: cytotoxicity and doxorubicin loading efficiency

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Publisher
de Gruyter
Copyright
© 2018 B. Divband et al., published by De Gruyter
ISSN
2391-5420
eISSN
2391-5420
DOI
10.1515/chem-2018-0001
Publisher site
See Article on Publisher Site

Abstract

AbstractDifferent cation-exchanged (K+, Na+ & Ca2+) nano-zeolites withi magnetite nanocomposites were synthesized and their suitability for drug loading was studied. Nanocomposites with different Fe3O4 contents were synthesized by adding magnetic Fe3O4 nanoparticles to the zeolite crystallization solution. The zeolite and its nanocomposites had high surface areas and enough adsorption capacity to load and release sufficient amounts of the chemotherapeutic doxorubicin. None or the zeolites or nanocomposites showed toxicity to SKBr3 or MCF-7 cancer cells. However, DOX@zeolite inhibits cell growth more than the non-encapsulated drug. Thus zeolites and their magnetite nanocomposites show potential as biocompatible medical devices.

Journal

Open Chemistryde Gruyter

Published: Feb 13, 2018

References