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Kinetics of green solid-liquid extraction of andrographolide from Andrographis paniculata : effects of particle size and solid-liquid ratio

Kinetics of green solid-liquid extraction of andrographolide from Andrographis paniculata :... Abstract In this work, the influences of particle size and solid-liquid ratio on the kinetics of green solid-liquid extraction of andrographolide from Andrographis paniculata (AP) were investigated. Kinetic experiments were performed in a pressurized liquid extractor under isothermal conditions at 80°C by varying the average particle size and solid-liquid ratio at various times. The identification and quantification of andrographolide concentration in the water extracts were carried out using high-performance liquid chromatography (HPLC). Kinetic data were fitted into first-order and second-order kinetics models with good correlation coefficients and coefficients of determination. However, the second-order rate law shows a better agreement with the experimental data. It was found that the observed specific extraction rate constants, k obs , increased to nearly twofold from 6.53×10 -4 l mg -1 min -1 to 1.28×10 -3 l mg -1 min -1 for solid-liquid ratio of 1:10 g ml -1 when particle size was decreased from 1.200 mm to 0.175 mm. In addition, k obs increased over fivefold, 3.44×10 -3 l mg -1 min -1 and almost fourfold, 4.96×10 -3 l mg -1 min -1 , for particle sizes of 1.200 mm and 0.175 mm with an overall rise of more than sevenfold when the solid-liquid ratio was increased to 1:50 g ml -1 , respectively. Therefore, k obs significantly increases with a decrease in particle size and an increase in solid-liquid ratio. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Green Processing and Synthesis de Gruyter

Kinetics of green solid-liquid extraction of andrographolide from Andrographis paniculata : effects of particle size and solid-liquid ratio

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Publisher
de Gruyter
Copyright
Copyright © 2015 by the
ISSN
2191-9542
eISSN
2191-9550
DOI
10.1515/gps-2015-0018
Publisher site
See Article on Publisher Site

Abstract

Abstract In this work, the influences of particle size and solid-liquid ratio on the kinetics of green solid-liquid extraction of andrographolide from Andrographis paniculata (AP) were investigated. Kinetic experiments were performed in a pressurized liquid extractor under isothermal conditions at 80°C by varying the average particle size and solid-liquid ratio at various times. The identification and quantification of andrographolide concentration in the water extracts were carried out using high-performance liquid chromatography (HPLC). Kinetic data were fitted into first-order and second-order kinetics models with good correlation coefficients and coefficients of determination. However, the second-order rate law shows a better agreement with the experimental data. It was found that the observed specific extraction rate constants, k obs , increased to nearly twofold from 6.53×10 -4 l mg -1 min -1 to 1.28×10 -3 l mg -1 min -1 for solid-liquid ratio of 1:10 g ml -1 when particle size was decreased from 1.200 mm to 0.175 mm. In addition, k obs increased over fivefold, 3.44×10 -3 l mg -1 min -1 and almost fourfold, 4.96×10 -3 l mg -1 min -1 , for particle sizes of 1.200 mm and 0.175 mm with an overall rise of more than sevenfold when the solid-liquid ratio was increased to 1:50 g ml -1 , respectively. Therefore, k obs significantly increases with a decrease in particle size and an increase in solid-liquid ratio.

Journal

Green Processing and Synthesisde Gruyter

Published: Oct 1, 2015

References