Meillet et al.: Intrathecal ß2-microglobulin and lysozyme syntheses in AIDS Eur. J. Clin. Chem. Clin. Biochem. Vol. 31, 1993, pp. 609-615 © 1993 Walter de Gruyter & Co. Berlin · New York Intrathecal Synthesis of ß2-Microglobulin and Lysozyme: Differential Markers of Nervous System Involvement in Patients Infected with Human Immunodeficiency Virus Type 1 By Dominique Meillet1, L. Belec2, Nicole Celton1, Annie Gervais2, Jocelyne Reboul2, M. Genlilini3, J. Delattre* and E. Schuller2 Laboratoire de Biochimie Laboratoire de Neuro-immunologie (INSERM U-134) 3 Service des Maladies Infectieuses et Tropicalesf Hopital de la Salpetrieret Paris, France (Received January 4/June 11, 1993) Summary: ß2-Microglobulin and lysozyme were determined in paired serum and cerebrospinal fluid samples from 137 patients, using immunofluorometry and ELlSA, respectively. Of these patients, 54 were infected by human immunodeficiency virus type l (HIV1) (including 20 AIDS dementia patients), 73 were HIV1seronegative with neurological diseases (meningitis (n = 10), multiple sclerosis (n = 29), other neurological diseases (n = 34)) and 10 were controls. Intrathecal synthesis of ß2-microglobulin occurred in each group. Conversely, lysozyme intrathecal synthesis was found only in meningitis (10/10) and in HIVI-infection (24/54). A pathological increase in ß2-microglobulin intrathecal synthesis (> 2mg/l) was observed in 45 patients (34
Clinical Chemistry and Laboratory Medicine – de Gruyter
Published: Jan 1, 1993
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