Interlaboratory Surveys of the Determination of Tumour Markers Scatter and Repeatability of the Results

Interlaboratory Surveys of the Determination of Tumour Markers Scatter and Repeatability of the... Introduction During the last decade, in the field of tumour diagnosis, many more quantitative determinations for tumour markers have become available, and the number of these determinations requested and performed has also markedly increased. The determination methods are based exclusively on immunochemical principles, whose complex procedures are more subject to systematic and random errors, compared with many procedures of more traditional clinical chemical analysis. Soon after the introduction of the determination of tumour markers, the necessity arose to test the reliability of the analytical results in collaborative interlaboratory surveys, as far as this was possible under the preconditions laid down for such tests (1). Since 1981, regular iiiterlaboratory surveys of tumour markers have been carried out in collaboration with the German Society for Clinical Chemistry. The first interlaboratory surveys were conducted on three tumour markers: -fetoprotein, carcinoembryonic antigen and human chorionic gonadotropin (2). By 1991 the Eur. J. Clin. Chem. Gin. Biochem. / Vol. 31,1993 / No. 3 number of tumour markers under survey had increased to 10 and, by the end of 1991, the number of participating laboratories to 430. More thorough investigations were promoted by the survey results of 1991, which revealed an especially wide scatter http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Clinical Chemistry and Laboratory Medicine de Gruyter

Interlaboratory Surveys of the Determination of Tumour Markers Scatter and Repeatability of the Results

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Publisher
de Gruyter
Copyright
Copyright © 2009 Walter de Gruyter
ISSN
1434-6621
eISSN
1437-4331
DOI
10.1515/cclm.1993.31.3.139
Publisher site
See Article on Publisher Site

Abstract

Introduction During the last decade, in the field of tumour diagnosis, many more quantitative determinations for tumour markers have become available, and the number of these determinations requested and performed has also markedly increased. The determination methods are based exclusively on immunochemical principles, whose complex procedures are more subject to systematic and random errors, compared with many procedures of more traditional clinical chemical analysis. Soon after the introduction of the determination of tumour markers, the necessity arose to test the reliability of the analytical results in collaborative interlaboratory surveys, as far as this was possible under the preconditions laid down for such tests (1). Since 1981, regular iiiterlaboratory surveys of tumour markers have been carried out in collaboration with the German Society for Clinical Chemistry. The first interlaboratory surveys were conducted on three tumour markers: -fetoprotein, carcinoembryonic antigen and human chorionic gonadotropin (2). By 1991 the Eur. J. Clin. Chem. Gin. Biochem. / Vol. 31,1993 / No. 3 number of tumour markers under survey had increased to 10 and, by the end of 1991, the number of participating laboratories to 430. More thorough investigations were promoted by the survey results of 1991, which revealed an especially wide scatter

Journal

Clinical Chemistry and Laboratory Medicinede Gruyter

Published: Jan 1, 1993

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