Increase of Serum α 1 -Acid Glycoprotein Despite the Decline of Liver Synthetic Function in Cirrhotics with Hepatocellular Carcinoma

Increase of Serum α 1 -Acid Glycoprotein Despite the Decline of Liver Synthetic Function in... Introduction at-Acid glycoprotein is a circulating glycoprotein synthesized mainly in the liver. It has a relative molecular mass of about 41000 and is characterized by the presence of five glycosylation sites (1, 2). arAcid glycoprotein has long been recognized as an acute phase reactant (3). Thus, its concentration increases 2--10 fold in serum, under conditions that promote the increase of other acute phase proteins such as a r antiproteinase and C-reactive protein; moreover, its synthesis in human adult hepatocytes is augmented Eur. J. Clin. Chem. Clin. Biochcm. / Vol. 31,1993 / No. 7 by interleukin-1 and interleukin-6, cytokines that are considered the main mediators of the acute phase response (4). Previous studies have shown that the at-acid glycoprotein concentration rises in serum during the course of several neoplastic diseases (5 -- 7), including hepatocellular carcinoma in Asian patients (8). However, hepatocellular carcinoma has a striking geographical variation and in industrialised countries, where its incidence is relatively low, hepatocellular Failed et al.: ocrAcid glycoprotein in hepatocellular carcinoma Biochemical determinations Sera were immediately stored at -20 °C after collection and kept frozen until use. At the time the determination of a,-acid glycoprotein was performed, sera h$d been stored for a http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Clinical Chemistry and Laboratory Medicine de Gruyter

Increase of Serum α 1 -Acid Glycoprotein Despite the Decline of Liver Synthetic Function in Cirrhotics with Hepatocellular Carcinoma

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Publisher
de Gruyter
Copyright
Copyright © 2009 Walter de Gruyter
ISSN
1434-6621
eISSN
1437-4331
DOI
10.1515/cclm.1993.31.7.407
Publisher site
See Article on Publisher Site

Abstract

Introduction at-Acid glycoprotein is a circulating glycoprotein synthesized mainly in the liver. It has a relative molecular mass of about 41000 and is characterized by the presence of five glycosylation sites (1, 2). arAcid glycoprotein has long been recognized as an acute phase reactant (3). Thus, its concentration increases 2--10 fold in serum, under conditions that promote the increase of other acute phase proteins such as a r antiproteinase and C-reactive protein; moreover, its synthesis in human adult hepatocytes is augmented Eur. J. Clin. Chem. Clin. Biochcm. / Vol. 31,1993 / No. 7 by interleukin-1 and interleukin-6, cytokines that are considered the main mediators of the acute phase response (4). Previous studies have shown that the at-acid glycoprotein concentration rises in serum during the course of several neoplastic diseases (5 -- 7), including hepatocellular carcinoma in Asian patients (8). However, hepatocellular carcinoma has a striking geographical variation and in industrialised countries, where its incidence is relatively low, hepatocellular Failed et al.: ocrAcid glycoprotein in hepatocellular carcinoma Biochemical determinations Sera were immediately stored at -20 °C after collection and kept frozen until use. At the time the determination of a,-acid glycoprotein was performed, sera h$d been stored for a

Journal

Clinical Chemistry and Laboratory Medicinede Gruyter

Published: Jan 1, 1993

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