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In vitro activity of allicin combined with two antibiotics on intestinal Shigella

In vitro activity of allicin combined with two antibiotics on intestinal Shigella AbstractObjectiveWe aimed to evaluate the combined antibacterial effects of allicin in combination with levofloxacin and ceftriaxone on Shigella isolated from the intestinal tract in vitro.Materials and MethodsUsing a checkerboard design, broth microdilution assay was used to test the effects of the compounds on the organism. We also determined the MIC of the two groups of antibacterial drugs against 30 strains of Shigella and calculated the fractional inhibitory concentration (FIC) index, to judge the combination effect.ResultAfter the combined application of allicin and ceftriaxone the MIC decreased significantly. Distribution of the FIC index was as follows: FIC ≤0.5, accounting for 10%; 0.5< FIC ≤1.0, accounting for 60%; 1 < FIC ≤2, accounting for 30%; FIC >2, percentage is zero. After combined application of allicin and levofloxacin, distribution of FIC index was as follows: FIC≤0.5, ratio is zero; 0.5< FIC ≤1, accounting for 56.7%; 1 < FIC ≤2, accounting for 43.3%; FIC >2, ratio is zero.ConclusionAfter the combined use of ceftriaxone, levofloxacin, and allicin, most of the tests showed synergistic effects and additive effects on Shigella, while some of them showed no correlation and no antagonistic effect. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Infection International de Gruyter

In vitro activity of allicin combined with two antibiotics on intestinal Shigella

Jia, Yuchi; Wu, Xiaomei
Infection International , Volume 6 (1): 5 – Nov 28, 2017
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Publisher
de Gruyter
Copyright
© 2017 Walter de Gruyter GmbH, Berlin/Boston
eISSN
2544-0349
DOI
10.1515/ii-2017-0152
Publisher site
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Abstract

AbstractObjectiveWe aimed to evaluate the combined antibacterial effects of allicin in combination with levofloxacin and ceftriaxone on Shigella isolated from the intestinal tract in vitro.Materials and MethodsUsing a checkerboard design, broth microdilution assay was used to test the effects of the compounds on the organism. We also determined the MIC of the two groups of antibacterial drugs against 30 strains of Shigella and calculated the fractional inhibitory concentration (FIC) index, to judge the combination effect.ResultAfter the combined application of allicin and ceftriaxone the MIC decreased significantly. Distribution of the FIC index was as follows: FIC ≤0.5, accounting for 10%; 0.5< FIC ≤1.0, accounting for 60%; 1 < FIC ≤2, accounting for 30%; FIC >2, percentage is zero. After combined application of allicin and levofloxacin, distribution of FIC index was as follows: FIC≤0.5, ratio is zero; 0.5< FIC ≤1, accounting for 56.7%; 1 < FIC ≤2, accounting for 43.3%; FIC >2, ratio is zero.ConclusionAfter the combined use of ceftriaxone, levofloxacin, and allicin, most of the tests showed synergistic effects and additive effects on Shigella, while some of them showed no correlation and no antagonistic effect.

Journal

Infection International – de Gruyter

Published: Nov 28, 2017

References

  • Allicin, the antibacterial principle of Allium sativum. Determination of the chemical structure
  • History, folk medicine, and legendary uses of garlic, In: H.P. Koch, L.D. Lawson (Eds.), Garlic: the science and therapeutic application of Allium sativum L. and related species
  • Antimicrobial properties of allicin from garlic
  • Antimicrobial properties of allium species
  • Antimicrobial properties of allium species
  • Recent advances in research of garlic’s chemical constituents and theirs pharmacological effects
  • Antimalarial activity of allicin, a biologically active compound from garlic cloves
  • Antibacterial potential of garlic-derived allicin and its cancellation by sulfhydryl compounds
  • Antimicrobial properties of allicin from garlic
  • History, folk medicine, and legendary uses of garlic, In: H.P. Koch, L.D. Lawson (Eds.), Garlic: the science and therapeutic application of Allium sativum L. and related species
  • In vitro activity of garlic oil and four diallyl sulphides against antibiotic-resistant Pseudomonas aeruginosa and Klebsiella pneumoniae
  • Antibacterial potential of garlic-derived allicin and its cancellation by sulfhydryl compounds
  • In vitro activity of garlic oil and four diallyl sulphides against antibiotic-resistant Pseudomonas aeruginosa and Klebsiella pneumoniae
  • Inhibitory effect of garlic extract on oral bacteria
  • Inhibitory effect of garlic extract on oral bacteria
  • Antimalarial activity of allicin, a biologically active compound from garlic cloves
  • Recent advances in research of garlic’s chemical constituents and theirs pharmacological effects
  • Allicin, the antibacterial principle of Allium sativum. Determination of the chemical structure
  • Garlic natural health products exhibit variable constituent levels and antimicrobial activity against Neisseria gonorrhoeae, Staphylococcus aureus and Enterococcus faecalis
  • Garlic natural health products exhibit variable constituent levels and antimicrobial activity against Neisseria gonorrhoeae, Staphylococcus aureus and Enterococcus faecalis