Immunological and Functional Properties of the Acetylcholine Receptor Expressed on the Human Cell Line TE671

Immunological and Functional Properties of the Acetylcholine Receptor Expressed on the Human Cell... Introduction . '· n /< o\ ? · · * - immunologically (1, 2). For immunological studies in Autoantibodies direct against the human äcetylcho- myasthenia gravis these receptors are less useful beline receptor are known to play an important role in^ cause of their low cross-reactivity to human acetylthe pathogenesis of myasthenia gravis. However, iso^· choline receptor (3, 4). Therefore, human acetylcholation of the target structure, the acetylcholine recep-' line receptor from amputated leg muscle tissue has tor from human muscle tissue, is difficult and various usually been applied as autoantigen in different aspreparations differ in their antigenicity. As an alter- says. However, the supply of human muscle is limited native we isolated the acetylcholine receptor from the and more importantly, during the preparation human human cell line TE671 and investigated its reaction muscle acetylcholine receptor is easily degraded (5, with human autoantibodies immunologically and 6). The human TE671 cell line expresses significant functionally. numbers of acetylcholine receptors and is therefore a rTM . . . , t i· .· ,, .,- , useful alternative source for acetylcholine receptor The nicotimc acetylcholine receptor, initially purified ,. ^,. ,, ,. . ... ,, , ., , J , . http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Clinical Chemistry and Laboratory Medicine de Gruyter

Immunological and Functional Properties of the Acetylcholine Receptor Expressed on the Human Cell Line TE671

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Publisher
de Gruyter
Copyright
Copyright © 2009 Walter de Gruyter
ISSN
1434-6621
eISSN
1437-4331
DOI
10.1515/cclm.1993.31.10.657
Publisher site
See Article on Publisher Site

Abstract

Introduction . '· n /< o\ ? · · * - immunologically (1, 2). For immunological studies in Autoantibodies direct against the human äcetylcho- myasthenia gravis these receptors are less useful beline receptor are known to play an important role in^ cause of their low cross-reactivity to human acetylthe pathogenesis of myasthenia gravis. However, iso^· choline receptor (3, 4). Therefore, human acetylcholation of the target structure, the acetylcholine recep-' line receptor from amputated leg muscle tissue has tor from human muscle tissue, is difficult and various usually been applied as autoantigen in different aspreparations differ in their antigenicity. As an alter- says. However, the supply of human muscle is limited native we isolated the acetylcholine receptor from the and more importantly, during the preparation human human cell line TE671 and investigated its reaction muscle acetylcholine receptor is easily degraded (5, with human autoantibodies immunologically and 6). The human TE671 cell line expresses significant functionally. numbers of acetylcholine receptors and is therefore a rTM . . . , t i· .· ,, .,- , useful alternative source for acetylcholine receptor The nicotimc acetylcholine receptor, initially purified ,. ^,. ,, ,. . ... ,, , ., , J , .

Journal

Clinical Chemistry and Laboratory Medicinede Gruyter

Published: Jan 1, 1993

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