Introduction . '· n /< o\ ? · · * - immunologically (1, 2). For immunological studies in Autoantibodies direct against the human äcetylcho- myasthenia gravis these receptors are less useful beline receptor are known to play an important role in^ cause of their low cross-reactivity to human acetylthe pathogenesis of myasthenia gravis. However, iso^· choline receptor (3, 4). Therefore, human acetylcholation of the target structure, the acetylcholine recep-' line receptor from amputated leg muscle tissue has tor from human muscle tissue, is difficult and various usually been applied as autoantigen in different aspreparations differ in their antigenicity. As an alter- says. However, the supply of human muscle is limited native we isolated the acetylcholine receptor from the and more importantly, during the preparation human human cell line TE671 and investigated its reaction muscle acetylcholine receptor is easily degraded (5, with human autoantibodies immunologically and 6). The human TE671 cell line expresses significant functionally. numbers of acetylcholine receptors and is therefore a rTM . . . , t i· .· ,, .,- , useful alternative source for acetylcholine receptor The nicotimc acetylcholine receptor, initially purified ,. ^,. ,, ,. . ... ,, , ., , J , .
Clinical Chemistry and Laboratory Medicine – de Gruyter
Published: Jan 1, 1993
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.
Read from thousands of the leading scholarly journals from SpringerNature, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera