C.Lowy Diabetes and Endocrine Unit, Department of Medicine, UMDS, St Thomas'Hospital, London SEI 7EH, UK INTRODUCTION Whilst hypoglycaemia is a common manifestation in children with GH deficiency, this is seldom a clinical problem in GH deficient adults. However, when GH deficiency occurs in insulin dependent diabetic adults, hypoglycaemic attacks are more frequent, prolonged and life threatening /1,2/. Spontaneous resolution of retinopathy in a woman who infarcted her pituitary gland led to pituitary ablation as a form of treatment /3/. In spite of GH being implicated in the pathogenesis of diabetic retinopathy, GH replacement therapy was undertaken in FG because the quality of her life became unacceptable. finally convinced her that she could not achieve adequate glycaemic control on a single daily injection of insulin. In 1980 HbAl measurements were introduced into our clinic, allowing an independent estimate of her blood glucose control. Her first and second pregnancies in 1981 and 1983 were relatively uneventful. In 1986 at 31 weeks gestation she developed a severe headache; a subarachnoid haemorrhage was suspected but the cerebrospinal fluid contained no excess red or white cells. She remained nauseous with a very poor appetite requiring much smaller insulin doses. An elective Caesarian section
Journal of Pediatric Endocrinology and Metabolism – de Gruyter
Published: Jan 1, 1993
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