Growth Hormone Replacement in a Hypopituitary Insulin Dependent Woman

Growth Hormone Replacement in a Hypopituitary Insulin Dependent Woman C.Lowy Diabetes and Endocrine Unit, Department of Medicine, UMDS, St Thomas'Hospital, London SEI 7EH, UK INTRODUCTION Whilst hypoglycaemia is a common manifestation in children with GH deficiency, this is seldom a clinical problem in GH deficient adults. However, when GH deficiency occurs in insulin dependent diabetic adults, hypoglycaemic attacks are more frequent, prolonged and life threatening /1,2/. Spontaneous resolution of retinopathy in a woman who infarcted her pituitary gland led to pituitary ablation as a form of treatment /3/. In spite of GH being implicated in the pathogenesis of diabetic retinopathy, GH replacement therapy was undertaken in FG because the quality of her life became unacceptable. finally convinced her that she could not achieve adequate glycaemic control on a single daily injection of insulin. In 1980 HbAl measurements were introduced into our clinic, allowing an independent estimate of her blood glucose control. Her first and second pregnancies in 1981 and 1983 were relatively uneventful. In 1986 at 31 weeks gestation she developed a severe headache; a subarachnoid haemorrhage was suspected but the cerebrospinal fluid contained no excess red or white cells. She remained nauseous with a very poor appetite requiring much smaller insulin doses. An elective Caesarian section http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Pediatric Endocrinology and Metabolism de Gruyter

Growth Hormone Replacement in a Hypopituitary Insulin Dependent Woman

Loading next page...
 
/lp/de-gruyter/growth-hormone-replacement-in-a-hypopituitary-insulin-dependent-woman-5LayOP9thj
Publisher
de Gruyter
Copyright
Copyright © 1993 by the
ISSN
0334-018X
eISSN
2191-0251
DOI
10.1515/JPEM.1993.6.1.61
Publisher site
See Article on Publisher Site

Abstract

C.Lowy Diabetes and Endocrine Unit, Department of Medicine, UMDS, St Thomas'Hospital, London SEI 7EH, UK INTRODUCTION Whilst hypoglycaemia is a common manifestation in children with GH deficiency, this is seldom a clinical problem in GH deficient adults. However, when GH deficiency occurs in insulin dependent diabetic adults, hypoglycaemic attacks are more frequent, prolonged and life threatening /1,2/. Spontaneous resolution of retinopathy in a woman who infarcted her pituitary gland led to pituitary ablation as a form of treatment /3/. In spite of GH being implicated in the pathogenesis of diabetic retinopathy, GH replacement therapy was undertaken in FG because the quality of her life became unacceptable. finally convinced her that she could not achieve adequate glycaemic control on a single daily injection of insulin. In 1980 HbAl measurements were introduced into our clinic, allowing an independent estimate of her blood glucose control. Her first and second pregnancies in 1981 and 1983 were relatively uneventful. In 1986 at 31 weeks gestation she developed a severe headache; a subarachnoid haemorrhage was suspected but the cerebrospinal fluid contained no excess red or white cells. She remained nauseous with a very poor appetite requiring much smaller insulin doses. An elective Caesarian section

Journal

Journal of Pediatric Endocrinology and Metabolismde Gruyter

Published: Jan 1, 1993

There are no references for this article.

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create folders to
organize your research

Export folders, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off