Growth Hormone (GH) Treatment in Achondroplasia

Growth Hormone (GH) Treatment in Achondroplasia T. Yamate, S. Kanzaki, H. Tanaka, T. Kubo, T. Moriwake, M. Inoue and Y. Seino* Department of Pediatrics, Okayama University Medical School 2-5-1 Shikata-choy Okayama 700, Japan SYNOPSIS Achondroplasia is one of the most commonly nown types of skeletal dysplasia in the adult ading to short stature* Before beginning owth hormone (GH) treatment of short staire in patients with achondroplasia, we valuated their growth pattern and their ypothalamic-pituitary function, including GH ecretion. We studied 22 patients with chondroplasia (7 males and 15 females: age ange, 3 to 12 years). The z-score of their height at admission was 5.4±1.2 (mean ± SD), and that of their annual eight gain before admission was -3.1 ± 1 3 mean ± SD). GH response to provocative tests /as normal in all patients except five: four howed subnormal (<10 ng/ml) response to L)opa stimuli, and one patient showed subnormal (<20 ng/ml) response to GRF stimuli, \"he mean GH concentration during sleep was ound to be low (<5 ng/ml) in three patients, rhese three patients were suspected to have atent GH deficiency, as they also showed a narkedly low IGF-1 level and marked delay of >one age. LH, FSH, TSH, and Cortisol response ο http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Pediatric Endocrinology and Metabolism de Gruyter

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Publisher
de Gruyter
Copyright
Copyright © 1993 by the
ISSN
0334-018X
eISSN
2191-0251
DOI
10.1515/JPEM.1993.6.1.45
Publisher site
See Article on Publisher Site

Abstract

T. Yamate, S. Kanzaki, H. Tanaka, T. Kubo, T. Moriwake, M. Inoue and Y. Seino* Department of Pediatrics, Okayama University Medical School 2-5-1 Shikata-choy Okayama 700, Japan SYNOPSIS Achondroplasia is one of the most commonly nown types of skeletal dysplasia in the adult ading to short stature* Before beginning owth hormone (GH) treatment of short staire in patients with achondroplasia, we valuated their growth pattern and their ypothalamic-pituitary function, including GH ecretion. We studied 22 patients with chondroplasia (7 males and 15 females: age ange, 3 to 12 years). The z-score of their height at admission was 5.4±1.2 (mean ± SD), and that of their annual eight gain before admission was -3.1 ± 1 3 mean ± SD). GH response to provocative tests /as normal in all patients except five: four howed subnormal (<10 ng/ml) response to L)opa stimuli, and one patient showed subnormal (<20 ng/ml) response to GRF stimuli, \"he mean GH concentration during sleep was ound to be low (<5 ng/ml) in three patients, rhese three patients were suspected to have atent GH deficiency, as they also showed a narkedly low IGF-1 level and marked delay of >one age. LH, FSH, TSH, and Cortisol response ο

Journal

Journal of Pediatric Endocrinology and Metabolismde Gruyter

Published: Jan 1, 1993

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