Gas Chromatographic Estimation of Homovanillic Acid in Serum of Normals and Psychotic Patients

Gas Chromatographic Estimation of Homovanillic Acid in Serum of Normals and Psychotic Patients Introduction Homovanillic acid (4-hydroxy^3^methoxyphenylacetic acid) is considered to be the main metabolite of dopamine in the brain. It has been detected in brain tissue and cerebrospinal fluid (CSF) ( --3) and its concentration in CSF may reflect the central dopamine turnover (for review see I.e. (4)). Dopamine is metabolized by the alternative action of monoamine pxidase and catechol-Q-methyltransferase; the 0-methylated and oxidatively deaminated product, an aldehyde, is further oxidized to the acid by aldehyde dehydrogenase. The O-methylation can take place at the 4-QH group of dopamine, whereby isö-hömovanillic acid is produced. It has been detected in small amounts in CSF (5, 6). J. Clin. Chem. Clin. Biochem.,/ Vol. 14,1976 / No. 9 An active transport system, sensitive to probenecid, removes homovanillic acid from the brain to CSF and from CSF to the blood (7). It is localized in the region of the fourth ventricle (8). In CSF, there is a gradient in the homovanillic acid concentration: in man, the concentration falls from 466 £/1 in the ventricular CSF to 185 in the cisternal and to 53 /ig/1 in the lumbar CSF (9). In lumbar CSF, the concentration of homovanillic acid depends greatly on the conditions under which the http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Clinical Chemistry and Laboratory Medicine de Gruyter

Gas Chromatographic Estimation of Homovanillic Acid in Serum of Normals and Psychotic Patients

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Publisher
de Gruyter
Copyright
Copyright © 2009 Walter de Gruyter
ISSN
1434-6621
eISSN
1437-4331
DOI
10.1515/cclm.1976.14.1-12.437
Publisher site
See Article on Publisher Site

Abstract

Introduction Homovanillic acid (4-hydroxy^3^methoxyphenylacetic acid) is considered to be the main metabolite of dopamine in the brain. It has been detected in brain tissue and cerebrospinal fluid (CSF) ( --3) and its concentration in CSF may reflect the central dopamine turnover (for review see I.e. (4)). Dopamine is metabolized by the alternative action of monoamine pxidase and catechol-Q-methyltransferase; the 0-methylated and oxidatively deaminated product, an aldehyde, is further oxidized to the acid by aldehyde dehydrogenase. The O-methylation can take place at the 4-QH group of dopamine, whereby isö-hömovanillic acid is produced. It has been detected in small amounts in CSF (5, 6). J. Clin. Chem. Clin. Biochem.,/ Vol. 14,1976 / No. 9 An active transport system, sensitive to probenecid, removes homovanillic acid from the brain to CSF and from CSF to the blood (7). It is localized in the region of the fourth ventricle (8). In CSF, there is a gradient in the homovanillic acid concentration: in man, the concentration falls from 466 £/1 in the ventricular CSF to 185 in the cisternal and to 53 /ig/1 in the lumbar CSF (9). In lumbar CSF, the concentration of homovanillic acid depends greatly on the conditions under which the

Journal

Clinical Chemistry and Laboratory Medicinede Gruyter

Published: Jan 1, 1976

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