Introduction Homovanillic acid (4-hydroxy^3^methoxyphenylacetic acid) is considered to be the main metabolite of dopamine in the brain. It has been detected in brain tissue and cerebrospinal fluid (CSF) ( --3) and its concentration in CSF may reflect the central dopamine turnover (for review see I.e. (4)). Dopamine is metabolized by the alternative action of monoamine pxidase and catechol-Q-methyltransferase; the 0-methylated and oxidatively deaminated product, an aldehyde, is further oxidized to the acid by aldehyde dehydrogenase. The O-methylation can take place at the 4-QH group of dopamine, whereby isö-hömovanillic acid is produced. It has been detected in small amounts in CSF (5, 6). J. Clin. Chem. Clin. Biochem.,/ Vol. 14,1976 / No. 9 An active transport system, sensitive to probenecid, removes homovanillic acid from the brain to CSF and from CSF to the blood (7). It is localized in the region of the fourth ventricle (8). In CSF, there is a gradient in the homovanillic acid concentration: in man, the concentration falls from 466 £/1 in the ventricular CSF to 185 in the cisternal and to 53 /ig/1 in the lumbar CSF (9). In lumbar CSF, the concentration of homovanillic acid depends greatly on the conditions under which the
Clinical Chemistry and Laboratory Medicine – de Gruyter
Published: Jan 1, 1976
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.
Read from thousands of the leading scholarly journals from SpringerNature, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera