Falsely Low Results in CA 125 Determination Due to Anti-Idiotypic Antibodies Induced by Infusion of 131 IF(ab′)2 Fragments of the OC125 Antibody

Falsely Low Results in CA 125 Determination Due to Anti-Idiotypic Antibodies Induced by Infusion... Introduction applied F(ab')2 fragments are formed as well (9). ,, - - . r · These anti-idiotypic antibodies interfere with the deFor the last couple of years the murme monoclonal . . , , . r If. .,, *-u r^r-4~>c · ·*·" 11 j i j u D * + /< homologous immuantibody OC125, initially developed by Bast et al. (1, termination of CA 125 when a ., .. . ., ^~4~c , , , -v «. . \ . . * 4.· r nometnc assay with OC125 antibodies as bothu the 2) to measure immunometncallynthe concentration of . _ .t. , , , . , ,, , .. , . , _ «ic · *i. r · *· * . immobilized and the labelled antibody is used. In an CA 125 in the serum of ovarian cancer patients, has ^i-i··, ···,· ·, ,. , . j. . ,. . j . . assay of this kind, anti-idiotypic antibodies can crossf also been used in vivo r radioimmunodetection of ,. , , , for ., !. , :, . ^ , , , . , /-A 125/-» A\ -n 4.1 4. * that · ' both ... antibodies, http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Clinical Chemistry and Laboratory Medicine de Gruyter

Falsely Low Results in CA 125 Determination Due to Anti-Idiotypic Antibodies Induced by Infusion of 131 IF(ab′)2 Fragments of the OC125 Antibody

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Publisher
de Gruyter
Copyright
Copyright © 2009 Walter de Gruyter
ISSN
1434-6621
eISSN
1437-4331
DOI
10.1515/cclm.1993.31.5.323
Publisher site
See Article on Publisher Site

Abstract

Introduction applied F(ab')2 fragments are formed as well (9). ,, - - . r · These anti-idiotypic antibodies interfere with the deFor the last couple of years the murme monoclonal . . , , . r If. .,, *-u r^r-4~>c · ·*·" 11 j i j u D * + /< homologous immuantibody OC125, initially developed by Bast et al. (1, termination of CA 125 when a ., .. . ., ^~4~c , , , -v «. . \ . . * 4.· r nometnc assay with OC125 antibodies as bothu the 2) to measure immunometncallynthe concentration of . _ .t. , , , . , ,, , .. , . , _ «ic · *i. r · *· * . immobilized and the labelled antibody is used. In an CA 125 in the serum of ovarian cancer patients, has ^i-i··, ···,· ·, ,. , . j. . ,. . j . . assay of this kind, anti-idiotypic antibodies can crossf also been used in vivo r radioimmunodetection of ,. , , , for ., !. , :, . ^ , , , . , /-A 125/-» A\ -n 4.1 4. * that · ' both ... antibodies,

Journal

Clinical Chemistry and Laboratory Medicinede Gruyter

Published: Jan 1, 1993

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