Establishment of Reference Ranges for Prolactin in Neonates, Infants, Children and Adolescents

Establishment of Reference Ranges for Prolactin in Neonates, Infants, Children and Adolescents Introduction The aim of the investigation was: 1) to determine the reference ranges for serum prolactin in healthy neonates, infants, children and adolescents; 2) to test for significant sex differences in serum prolactin concentration within the reference groups; and 3) to test for significant differences in serum prolactin concentration between the reference groups. Materials and Methods Prolactin was determined in the sera of 686 healthy neonates, infants, children and adolescents (age range 5 days to 18 years). In the course of routine screening for hypothyreosis venous blood was taken from 5-day-old neonates. For all other probands blood samples wer taken after written consent was obtained from their parents, who were informed as to the purpose of the tests. The Ethics Commission of the Medical School of Erfurt gave its agreement for this purpose. The age composition Serum prolactin is measured in childhood mainly as a means of establishing the presence or absence of increased prolactin secretion. The causes of hyperprplactinaemia are complex. Particularly important are pituitary tumours or other encroachments on space, which compress the pituitary stem and prevent inhibitory factors from reaching the site of prolactin secretion (1 -- 3). Excessive prolactin production may not be clearly http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Clinical Chemistry and Laboratory Medicine de Gruyter

Establishment of Reference Ranges for Prolactin in Neonates, Infants, Children and Adolescents

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Publisher
de Gruyter
Copyright
Copyright © 2009 Walter de Gruyter
ISSN
1434-6621
eISSN
1437-4331
DOI
10.1515/cclm.1993.31.7.447
Publisher site
See Article on Publisher Site

Abstract

Introduction The aim of the investigation was: 1) to determine the reference ranges for serum prolactin in healthy neonates, infants, children and adolescents; 2) to test for significant sex differences in serum prolactin concentration within the reference groups; and 3) to test for significant differences in serum prolactin concentration between the reference groups. Materials and Methods Prolactin was determined in the sera of 686 healthy neonates, infants, children and adolescents (age range 5 days to 18 years). In the course of routine screening for hypothyreosis venous blood was taken from 5-day-old neonates. For all other probands blood samples wer taken after written consent was obtained from their parents, who were informed as to the purpose of the tests. The Ethics Commission of the Medical School of Erfurt gave its agreement for this purpose. The age composition Serum prolactin is measured in childhood mainly as a means of establishing the presence or absence of increased prolactin secretion. The causes of hyperprplactinaemia are complex. Particularly important are pituitary tumours or other encroachments on space, which compress the pituitary stem and prevent inhibitory factors from reaching the site of prolactin secretion (1 -- 3). Excessive prolactin production may not be clearly

Journal

Clinical Chemistry and Laboratory Medicinede Gruyter

Published: Jan 1, 1993

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