Introduction The aim of the investigation was: 1) to determine the reference ranges for serum prolactin in healthy neonates, infants, children and adolescents; 2) to test for significant sex differences in serum prolactin concentration within the reference groups; and 3) to test for significant differences in serum prolactin concentration between the reference groups. Materials and Methods Prolactin was determined in the sera of 686 healthy neonates, infants, children and adolescents (age range 5 days to 18 years). In the course of routine screening for hypothyreosis venous blood was taken from 5-day-old neonates. For all other probands blood samples wer taken after written consent was obtained from their parents, who were informed as to the purpose of the tests. The Ethics Commission of the Medical School of Erfurt gave its agreement for this purpose. The age composition Serum prolactin is measured in childhood mainly as a means of establishing the presence or absence of increased prolactin secretion. The causes of hyperprplactinaemia are complex. Particularly important are pituitary tumours or other encroachments on space, which compress the pituitary stem and prevent inhibitory factors from reaching the site of prolactin secretion (1 -- 3). Excessive prolactin production may not be clearly
Clinical Chemistry and Laboratory Medicine – de Gruyter
Published: Jan 1, 1993
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