BioNanoMat 2015; 16(4): 301–308 Christine Neusser, Nicole Finocchiaro, Felix Hesselmann, Christian Cornelissen, Thomas Gries and Stefan Jockenhoevel* Endoxy – development and cultivation of textile-based gas membrane assemblies for endothelialized oxygenators DOI 10.1515/bnm-2015-0016 developed, which profit from a secondary flow arrange- Received July 31, 2015; accepted October 19, 2015; previously ment to increase gas transfer rates, the so-called Bell- published online November 12, 2015 house effect. Therefore textiles that allow a homogeneous gas flow between the membranes and provide a structure Abstract: One step to enable long-term use of extra- that can be used as mold for hollow imprinting onto the corporeal membrane oxygenation devices or even the membrane surfaces are combined with flat membranes to development of an artificial fully implantable lung is the a sandwich structure. On top of that two approaches for endothelialization of oxygenator membranes in order to hollow imprinting are generated and their results com- present a physiological and anti-thrombogenic surface to pared. The furrowed membrane assemblies are seeded the blood flow. Since cell seeding decreases the gas transfer with HUVECs and regularly inspected over 3 days cultiva- of oxygenation devices, a way to reincrease gas exchange tion. A surface characterization of the applied membranes performance by
BioNanoMaterials – de Gruyter
Published: Nov 1, 2015
Keywords: Bellhouse effect
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