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DRUG INTERACTIONS IN THE GUT INVOLVING METAL IONS

DRUG INTERACTIONS IN THE GUT INVOLVING METAL IONS DRUG INTERACTIONS E THE GUT INVOLVING METAL IONS M Department of Pharmacy, The Queen's University of Belfast, Medical Biology Centre, 97, Lisburn Road, Belfast BT9 7BL, Northern Ireland CONTENTS Page 1. INTRODUCTION 2. DRUG-FORMULATION INTERACTIONS 84 85 Tetracyclines Phenytoin 3. GASTROINTESTINAL ABSORPTION INTERACTIONS INVOLVING ANTACIDS Antiarrhythmics Cardiac Glycosides Chloroquine Cimetidine Oral Anticoagulants Phenytoin Tetracyclines Theophylline 4. CLINICAL SIGNIFICANCE OF INTERACTIONS IN THE GUT INVOLVING METAL IONS Changed Rate of Drug A bsorption Extent of Drug Absorption Drugs Involved in Clinically Important Drug Interactions 0334-2190-/85/02&3-0083-112@$.30/pg. © by Freund Publishing House, Ltd. Vol. 5, No. 2 & 3,1985 1. INTRODUCTION Drug interactions can occur at many different sites in the body and indeed all pharmacokinetic processes from absorption, distribution and metabolism, to elimination are susceptible to drug interactions. Interactions can also take place outside the body when, for example, a particular compound included in a drug formulation can influence the drug release characteristics from a dosage form. Before moving on to specific mechanisms of interactions in the gastrointestinal tract it is worthwhile to summarise the stages in drug absorption from the gut. When a drug is given by the oral route in a solid dosage form or suspension the drug http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Drug Metabolism and Drug Interactions de Gruyter

DRUG INTERACTIONS IN THE GUT INVOLVING METAL IONS

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References (94)

Publisher
de Gruyter
Copyright
Copyright © 1985 by the
ISSN
2191-0162
eISSN
2191-0162
DOI
10.1515/DMDI.1985.5.2-3.83
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Abstract

DRUG INTERACTIONS E THE GUT INVOLVING METAL IONS M Department of Pharmacy, The Queen's University of Belfast, Medical Biology Centre, 97, Lisburn Road, Belfast BT9 7BL, Northern Ireland CONTENTS Page 1. INTRODUCTION 2. DRUG-FORMULATION INTERACTIONS 84 85 Tetracyclines Phenytoin 3. GASTROINTESTINAL ABSORPTION INTERACTIONS INVOLVING ANTACIDS Antiarrhythmics Cardiac Glycosides Chloroquine Cimetidine Oral Anticoagulants Phenytoin Tetracyclines Theophylline 4. CLINICAL SIGNIFICANCE OF INTERACTIONS IN THE GUT INVOLVING METAL IONS Changed Rate of Drug A bsorption Extent of Drug Absorption Drugs Involved in Clinically Important Drug Interactions 0334-2190-/85/02&3-0083-112@$.30/pg. © by Freund Publishing House, Ltd. Vol. 5, No. 2 & 3,1985 1. INTRODUCTION Drug interactions can occur at many different sites in the body and indeed all pharmacokinetic processes from absorption, distribution and metabolism, to elimination are susceptible to drug interactions. Interactions can also take place outside the body when, for example, a particular compound included in a drug formulation can influence the drug release characteristics from a dosage form. Before moving on to specific mechanisms of interactions in the gastrointestinal tract it is worthwhile to summarise the stages in drug absorption from the gut. When a drug is given by the oral route in a solid dosage form or suspension the drug

Journal

Drug Metabolism and Drug Interactions – de Gruyter

Published: Jun 1, 1985

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