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Dose Independent Pharmacokinetics of Caffeine after Intravenous Administration under a Chronic Food-limited Regimen

Dose Independent Pharmacokinetics of Caffeine after Intravenous Administration under a Chronic... Curtis Smith*, Fang Ma** and Chyan E. Lau** *Department of Pharmacy Practice, Ferris State University College of Pharmacy, Lansing, MI, USA **Department of Psychology, Rutgers University, New Brunswick, NJ, USA SUMMARY Several studies have shown that caffeine follows non-linear pharmacokinetics in both rats and humans. Recent data have demonstrated that caffeine may following linear pharmacokinetics when administered orally and intraperitoneally to food-limited rats. In this study the pharmacokinetics of caffeine was analyzed following intravenous (IV) administration to rats under a food-limited regimen. Four rats were administered four doses of caffeine and a standard dose of the caffeine metabolites, paraxanthine, theobromine, and theophylline. Caffeine pharmacokinetic parameters were dose independent following intravenous doses ranging from 1 to 20 mg/kg. Furthermore, the caffeine area under the curve (AUC) increased linearly as a function of dose. The mean fraction of caffeine converted to paraxanthine, theobromine, and theophylline was 16%, 16%, and 7%, respectively. The linear pharmacokinetics demonstrated in the present study may be attributed to the induction of hepatic metabolism under a chronic food-limited regimen. Author for correspondence: Curtis Smith, Pharm.D. Sparrow Hospital, Dept. of Pharmacy 1215 E. Michigan Ave. Lansing, MI 48912, USA Email: curtis_smith@ferris.edu ©Freund Publishing House Ltd. 1999 83 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Drug Metabolism and Drug Interactions de Gruyter

Dose Independent Pharmacokinetics of Caffeine after Intravenous Administration under a Chronic Food-limited Regimen

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References (21)

Publisher
de Gruyter
Copyright
Copyright © 1999 by the
ISSN
2191-0162
eISSN
2191-0162
DOI
10.1515/DMDI.1999.15.1.83
Publisher site
See Article on Publisher Site

Abstract

Curtis Smith*, Fang Ma** and Chyan E. Lau** *Department of Pharmacy Practice, Ferris State University College of Pharmacy, Lansing, MI, USA **Department of Psychology, Rutgers University, New Brunswick, NJ, USA SUMMARY Several studies have shown that caffeine follows non-linear pharmacokinetics in both rats and humans. Recent data have demonstrated that caffeine may following linear pharmacokinetics when administered orally and intraperitoneally to food-limited rats. In this study the pharmacokinetics of caffeine was analyzed following intravenous (IV) administration to rats under a food-limited regimen. Four rats were administered four doses of caffeine and a standard dose of the caffeine metabolites, paraxanthine, theobromine, and theophylline. Caffeine pharmacokinetic parameters were dose independent following intravenous doses ranging from 1 to 20 mg/kg. Furthermore, the caffeine area under the curve (AUC) increased linearly as a function of dose. The mean fraction of caffeine converted to paraxanthine, theobromine, and theophylline was 16%, 16%, and 7%, respectively. The linear pharmacokinetics demonstrated in the present study may be attributed to the induction of hepatic metabolism under a chronic food-limited regimen. Author for correspondence: Curtis Smith, Pharm.D. Sparrow Hospital, Dept. of Pharmacy 1215 E. Michigan Ave. Lansing, MI 48912, USA Email: curtis_smith@ferris.edu ©Freund Publishing House Ltd. 1999 83

Journal

Drug Metabolism and Drug Interactionsde Gruyter

Published: Mar 1, 1999

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