Access the full text.
Sign up today, get DeepDyve free for 14 days.
R. Latini, M. Bonati, D. Castelli, S. Garattini (1978)
Dose-dependent kinetics of caffeine in ratsToxicology Letters, 2
D. Sachan (1982)
Modulation of drug metabolism by food restriction in male rats.Biochemical and biophysical research communications, 104 3
W. Tassaneeyakul, D. Birkett, Michael McManus, W. Tassaneeyakul, M. Veronese, Tommy Andersson, R. Tukey, J. Miners (1994)
Caffeine metabolism by human hepatic cytochromes P450: contributions of 1A2, 2E1 and 3A isoforms.Biochemical pharmacology, 47 10
G. Pincomb, W. Lovallo, R. Passey, M. Wilson (1988)
Effect of behavior state on caffeine's ability to alter blood pressure.The American journal of cardiology, 61 10
A. Nehlig, J. Daval, G. Debry (1992)
Caffeine and the central nervous system: mechanisms of action, biochemical, metabolic and psychostimulant effectsBrain Research Reviews, 17
J. Leakey, H. Cunny, J. Bazare, P. Webb, J. Lipscomb, W. Slikker, R. Feuers, P. Duffy, R. Hart (1989)
Effects of aging and caloric restriction on hepatic drug metabolizing enzymes in the fischer 344 rat II: Effects on conjugating enzymesMechanisms of Ageing and Development, 48
S. Holtzman (1990)
Caffeine as a model drug of abuse.Trends in pharmacological sciences, 11 9
Gary Kaplan, David Greenblatt, M. Kent, M. Cotreau-Bibbo (1993)
Caffeine treatment and withdrawal in mice: relationships between dosage, concentrations, locomotor activity and A1 adenosine receptor binding.The Journal of pharmacology and experimental therapeutics, 266 3
C. Lau, F. Ma, J. Falk (1995)
Oral and IP caffeine pharmacokinetics under a chronic food-limitation conditionPharmacology Biochemistry and Behavior, 50
G. Schreiber, C. Maffeo, Morton Robins, M. Masters, Annell Bond (1988)
Measurement of coffee and caffeine intake: implications for epidemiologic research.Preventive medicine, 17 3
Vol . 15 , No . 1 , 1999 Dose Independent Pharmacokinetics of Caffeine chrome P - 450 dependent monooxygenase system
J. Leakey, H. Cunny, J. Bazare, P. Webb, R. Feuers, P. Duffy, R. Hart (1989)
Effects of aging and caloric restriction on hepatic drug metabolizing enzymes in the Fischer 344 rat. I: The cytochrome P-450 dependent monooxygenase systemMechanisms of Ageing and Development, 48
Somani Sm, P. Gupta (1988)
Caffeine: a new look at an age-old drug.International journal of clinical pharmacology, therapy, and toxicology, 26 11
D. Parke, C. Ioannides (1994)
The effects of nutrition on chemical toxicity.Drug metabolism reviews, 26 4
C. Lau, J. Falk (1991)
Sustained synergism by chronic caffeine of the motor control deficit produced by midazolamPharmacology Biochemistry and Behavior, 40
D. Tang-Liu, Roger Williams, S. Riegelman (1983)
Disposition of caffeine and its metabolites in man.The Journal of pharmacology and experimental therapeutics, 224 1
C. Denaro, Christopher Brown, Margaret Wilson, P. Jacob, N. Benowitz (1990)
Dose‐dependency of caffeine metabolism with repeated dosingClinical Pharmacology & Therapeutics, 48
J. Hong, J. Pan, F. Gonzalez, H. Gelboin, C. Yang (1987)
The induction of a specific form of cytochrome P-450 (P-450j) by fasting.Biochemical and biophysical research communications, 142 3
M. Bonati, S. Garattini (1984)
Interspecies Comparison of Caffeine Disposition
(1988)
Caffeine physical dependence: a review of human and laboratory studies
Wendy Cheng, T. Murphy, Maree Smith, W. Cooksley, J. Halliday, L. Powell (1990)
Dose‐dependent pharmacokinetics of caffeine in humans: Relevance as a test of quantitative liver functionClinical Pharmacology & Therapeutics, 47
Curtis Smith*, Fang Ma** and Chyan E. Lau** *Department of Pharmacy Practice, Ferris State University College of Pharmacy, Lansing, MI, USA **Department of Psychology, Rutgers University, New Brunswick, NJ, USA SUMMARY Several studies have shown that caffeine follows non-linear pharmacokinetics in both rats and humans. Recent data have demonstrated that caffeine may following linear pharmacokinetics when administered orally and intraperitoneally to food-limited rats. In this study the pharmacokinetics of caffeine was analyzed following intravenous (IV) administration to rats under a food-limited regimen. Four rats were administered four doses of caffeine and a standard dose of the caffeine metabolites, paraxanthine, theobromine, and theophylline. Caffeine pharmacokinetic parameters were dose independent following intravenous doses ranging from 1 to 20 mg/kg. Furthermore, the caffeine area under the curve (AUC) increased linearly as a function of dose. The mean fraction of caffeine converted to paraxanthine, theobromine, and theophylline was 16%, 16%, and 7%, respectively. The linear pharmacokinetics demonstrated in the present study may be attributed to the induction of hepatic metabolism under a chronic food-limited regimen. Author for correspondence: Curtis Smith, Pharm.D. Sparrow Hospital, Dept. of Pharmacy 1215 E. Michigan Ave. Lansing, MI 48912, USA Email: curtis_smith@ferris.edu ©Freund Publishing House Ltd. 1999 83
Drug Metabolism and Drug Interactions – de Gruyter
Published: Mar 1, 1999
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.