Diurnal Variation of Plasma Cortisol Levels in Infancy

Diurnal Variation of Plasma Cortisol Levels in Infancy INTRODUCTION Normal children and adults show diurnal variation of plasma Cortisol levels reaching peak values around 08.00 h and lower values around 24.00 h. Despite numerous studies on diurnal variation of plasma Cortisol levels in children, the age of appearance of a circadian rhythm has not been definitely established. The purpose of this study was to investigate the development of Cortisol circadian rhythm in infancy. In seventy healthy, full-term infants, less than six months old, plasma Cortisol was measured at 10.30 h and 22.30 h. The mean ± SEM values of daytime plasma Cortisol at one to four weeks of life were 159 ± 41, 116 ± 43, 240± 54 and 456 ± 95 nmol/1 and the night-time values were 129 ± 40, 99 ± 44, 131 ± 78 and 430 ± 105 nmol/1, respectively. No statistically significant differences were found between daytime and night-time Cortisol values during the first four weeks of life. In contrast, the daytime values of plasma Cortisol were 295 ± 62 at the age of 2-3 months, 211 ± 43 at 4-5 months and 291± 31 nmol/1 at 6 months of life, and night-time values were 166 ± 52, 119 ± 35 and http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Pediatric Endocrinology and Metabolism de Gruyter

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Publisher
de Gruyter
Copyright
Copyright © 1998 by the
ISSN
0334-018X
eISSN
2191-0251
DOI
10.1515/JPEM.1998.11.4.549
Publisher site
See Article on Publisher Site

Abstract

INTRODUCTION Normal children and adults show diurnal variation of plasma Cortisol levels reaching peak values around 08.00 h and lower values around 24.00 h. Despite numerous studies on diurnal variation of plasma Cortisol levels in children, the age of appearance of a circadian rhythm has not been definitely established. The purpose of this study was to investigate the development of Cortisol circadian rhythm in infancy. In seventy healthy, full-term infants, less than six months old, plasma Cortisol was measured at 10.30 h and 22.30 h. The mean ± SEM values of daytime plasma Cortisol at one to four weeks of life were 159 ± 41, 116 ± 43, 240± 54 and 456 ± 95 nmol/1 and the night-time values were 129 ± 40, 99 ± 44, 131 ± 78 and 430 ± 105 nmol/1, respectively. No statistically significant differences were found between daytime and night-time Cortisol values during the first four weeks of life. In contrast, the daytime values of plasma Cortisol were 295 ± 62 at the age of 2-3 months, 211 ± 43 at 4-5 months and 291± 31 nmol/1 at 6 months of life, and night-time values were 166 ± 52, 119 ± 35 and

Journal

Journal of Pediatric Endocrinology and Metabolismde Gruyter

Published: Jul 1, 1998

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