Critical Evaluation of Measurement of Platelet Monoamine Oxidase in Man

Critical Evaluation of Measurement of Platelet Monoamine Oxidase in Man Introduction The substrate specificity and inhibitor sensitivity of monoamine oxidase (monoamine: O2 oxidoreductase (dearninating) EC 1.4.3.4) of human blood platelets are similar to those of monoamine oxidäse type B from human brain (1^-4). Since some abnormalities in the metabolism of biogenic amines in patients with mental disorders have been postulated (5, 6) several investigators have tried to correlate the activity of the platelet monoamine oxidase with the symptomatology and J. Clin. Chem. Clin. Biochem. / Vol. 14,1976 / No. 9 classification of mental diseases, thereby implying that a change of platelet monoamine oxidase may reflect an alteration of brain monoamine oxidase activity. Murphy et al (7, 8) using tryptamine found that platelet monoamine oxidase activity was reduced in chronic schizophrenics as well as in bipolar depressed patients. Nies et al (9), using benzylamine as substrate, reported *) A preliminary report of this study was presented at the 1st European Neurosciences Meeting, Munich, September 28, 1975. Honecker, Christ, M ller-Oerlinghausen and Coper: Critical evaluation of platelet monoamine oxidase in man Assay procedure of monoamine oxidase with tyramine, tryptamine and 0-phenylethylamine as substrates a) The standard assay contained in a final volume of 2.0 ml: platelet rich plasma/buffer mixture 1.2 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Clinical Chemistry and Laboratory Medicine de Gruyter

Critical Evaluation of Measurement of Platelet Monoamine Oxidase in Man

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Publisher
de Gruyter
Copyright
Copyright © 2009 Walter de Gruyter
ISSN
1434-6621
eISSN
1437-4331
DOI
10.1515/cclm.1976.14.1-12.453
Publisher site
See Article on Publisher Site

Abstract

Introduction The substrate specificity and inhibitor sensitivity of monoamine oxidase (monoamine: O2 oxidoreductase (dearninating) EC 1.4.3.4) of human blood platelets are similar to those of monoamine oxidäse type B from human brain (1^-4). Since some abnormalities in the metabolism of biogenic amines in patients with mental disorders have been postulated (5, 6) several investigators have tried to correlate the activity of the platelet monoamine oxidase with the symptomatology and J. Clin. Chem. Clin. Biochem. / Vol. 14,1976 / No. 9 classification of mental diseases, thereby implying that a change of platelet monoamine oxidase may reflect an alteration of brain monoamine oxidase activity. Murphy et al (7, 8) using tryptamine found that platelet monoamine oxidase activity was reduced in chronic schizophrenics as well as in bipolar depressed patients. Nies et al (9), using benzylamine as substrate, reported *) A preliminary report of this study was presented at the 1st European Neurosciences Meeting, Munich, September 28, 1975. Honecker, Christ, M ller-Oerlinghausen and Coper: Critical evaluation of platelet monoamine oxidase in man Assay procedure of monoamine oxidase with tyramine, tryptamine and 0-phenylethylamine as substrates a) The standard assay contained in a final volume of 2.0 ml: platelet rich plasma/buffer mixture 1.2

Journal

Clinical Chemistry and Laboratory Medicinede Gruyter

Published: Jan 1, 1976

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