Introduction The substrate specificity and inhibitor sensitivity of monoamine oxidase (monoamine: O2 oxidoreductase (dearninating) EC 22.214.171.124) of human blood platelets are similar to those of monoamine oxidäse type B from human brain (1^-4). Since some abnormalities in the metabolism of biogenic amines in patients with mental disorders have been postulated (5, 6) several investigators have tried to correlate the activity of the platelet monoamine oxidase with the symptomatology and J. Clin. Chem. Clin. Biochem. / Vol. 14,1976 / No. 9 classification of mental diseases, thereby implying that a change of platelet monoamine oxidase may reflect an alteration of brain monoamine oxidase activity. Murphy et al (7, 8) using tryptamine found that platelet monoamine oxidase activity was reduced in chronic schizophrenics as well as in bipolar depressed patients. Nies et al (9), using benzylamine as substrate, reported *) A preliminary report of this study was presented at the 1st European Neurosciences Meeting, Munich, September 28, 1975. Honecker, Christ, M ller-Oerlinghausen and Coper: Critical evaluation of platelet monoamine oxidase in man Assay procedure of monoamine oxidase with tyramine, tryptamine and 0-phenylethylamine as substrates a) The standard assay contained in a final volume of 2.0 ml: platelet rich plasma/buffer mixture 1.2
Clinical Chemistry and Laboratory Medicine – de Gruyter
Published: Jan 1, 1976
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.
Read from thousands of the leading scholarly journals from SpringerNature, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera