Jacob and Doss: Coproporphyrin isomers in porphyrias Eur. J. Clin. Chem. Clin. Biochem. Vol. 31, 1993, pp. 617-624 © 1993 Walter de Gruyter & Co. Berlin · New York Composition of Urinary Coproporphyrin Isomers I --IV in Human Porphyrias1) By K. Jacob1 and M. O. Doss2 Institut jur Klinische Chemie am Klinikum Gro hadern der Universit t M nchen, Germany Abteilung Klinische Biochemie, Fachbereich Humanmedizin, Philipps-Universit t, Marburg, Germany (Received March 19/June 24, 1993) Dedicated to Professor Claude Rimington in honour of his 90th birthday Summary: The urinary distribution and relative proportions of the four Coproporphyrin isomers I--IV were investigated in 50 patients suffering from hepatic and erythropoietic types of hereditary porphyrias. A highly efficient sample preparation method was applied to isolate urinary coproporphyrins, the isomer ratios of which were quantitated by isocratic ion-pair high-performance liquid chromatography. Results showed a significant decrease (p < 0.001) of the proportion of Coproporphyrin I in acute hepatic porphyria (acute intermittent porphyria, hereditary coproporphyria, variegate porphyria, porphobilinogen synthase deficiency porphyria) as compared with chronic hepatic porphyria (porphyria cutanea tarda, chronic hepatic porphyria type B and C) (13.2 ± 5.3%, ± S.D., vs. 31.4 ± 11.5%). Conversely, the proportion of isomer III was
Clinical Chemistry and Laboratory Medicine – de Gruyter
Published: Jan 1, 1993
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