Introduction Bilirubin is a well known negative interferent of the Jaffa method. There is some concern as to the degree of susceptibility for the phenol-aminophenazone peroxidase (PAP) method since compared with the Jaffe method in some studies (1, 2), the enzymatic assays for creatinine demonstrated less susceptibility to bilirubin and more as reported in others (3, 4). Moreover, published works suggest that conjugated bilirubin interferes more than unconjugated bilirubin in enzymatic assays (5, 6). Eur. J. Clin. Chem. Clin, Biochem. / Vol. 31,1993 / No. 12 , * r * j - - * j Our approach to interference studies is to derive a correlative equation by multiple regression analysis (7). The equation will contain terms which can be called analyte-dependent or analyte-independent. Analyte-independence is a term in which the degree of interference depends upon only the concentration of the interferent (8, 9). An example of this is pseudohyponatraemia is proportional only to the volume displacement caused by lipids. Another example is alkaline phosphatase, which when measured on the SMAC, is interfered by methotrexate because it ab- Eng et al.: Analyte-dcpendent/-indepcndent interferences by bilirubin on crcatinine PAP in biochemical measurements of patients. In this research, we studied the
Clinical Chemistry and Laboratory Medicine – de Gruyter
Published: Jan 1, 1993
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.
Read from thousands of the leading scholarly journals from SpringerNature, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera