Comparison of Direct Versus Indirect Determination of Zinc Concentration in Erythrocytes in Euthyroid and Hyperthyroid Subjects

Comparison of Direct Versus Indirect Determination of Zinc Concentration in Erythrocytes in... Introduction The interaction between thyroid function and zinc metabolism has long been a matter of investigation (1 -3). It is a well known fact that during hyperthyroidism the zinc concentration in erythrocytes decreases and serum zinc is increased (4, 5). The reason for the decreased erythrocyte zinc concentration is inhibition of the synthesis of carbonic anhydrase-I isoenzyme in erythrocytes by high thyroid hormone concentrations. The greatest amount of zinc in erythrocytes is bound as a structural part of this enzyme (6--8). Changes in erythrocyte zinc concentration, as a result of changes in thyroid function, take time to develop because of the relatively long half-life of erythrocytes. Therefore, erythrocyte zinc concentration reflects the patient's mean thyroid hormone conEur. J. Clin. Chem. Clin. Biochem. / Vol. 31,1993 / No. 4 centration over the previous several weeks and months (9, 10). For this reason it is possible to differentiate short from the long duration hyperthyroidism by determination of the erythrocyte zinc concentration. Lao et al. (11) reported that determination of erythrocyte zinc concentration makes it possible to discriminate between preexisting hyperthyroidism and transient hyperthyroidism in pregnancy due to hyperemesis gravidarum, and so facilitates the choice of therapy. Erythrocyte zinc concentration is http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Clinical Chemistry and Laboratory Medicine de Gruyter

Comparison of Direct Versus Indirect Determination of Zinc Concentration in Erythrocytes in Euthyroid and Hyperthyroid Subjects

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Publisher
de Gruyter
Copyright
Copyright © 2009 Walter de Gruyter
ISSN
1434-6621
eISSN
1437-4331
DOI
10.1515/cclm.1993.31.4.239
Publisher site
See Article on Publisher Site

Abstract

Introduction The interaction between thyroid function and zinc metabolism has long been a matter of investigation (1 -3). It is a well known fact that during hyperthyroidism the zinc concentration in erythrocytes decreases and serum zinc is increased (4, 5). The reason for the decreased erythrocyte zinc concentration is inhibition of the synthesis of carbonic anhydrase-I isoenzyme in erythrocytes by high thyroid hormone concentrations. The greatest amount of zinc in erythrocytes is bound as a structural part of this enzyme (6--8). Changes in erythrocyte zinc concentration, as a result of changes in thyroid function, take time to develop because of the relatively long half-life of erythrocytes. Therefore, erythrocyte zinc concentration reflects the patient's mean thyroid hormone conEur. J. Clin. Chem. Clin. Biochem. / Vol. 31,1993 / No. 4 centration over the previous several weeks and months (9, 10). For this reason it is possible to differentiate short from the long duration hyperthyroidism by determination of the erythrocyte zinc concentration. Lao et al. (11) reported that determination of erythrocyte zinc concentration makes it possible to discriminate between preexisting hyperthyroidism and transient hyperthyroidism in pregnancy due to hyperemesis gravidarum, and so facilitates the choice of therapy. Erythrocyte zinc concentration is

Journal

Clinical Chemistry and Laboratory Medicinede Gruyter

Published: Jan 1, 1993

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