Obesity is common in children with congenital midline defects of the brain, due to various endocrine reasons: hypothyroidism, growth hormone deficiency and inappropriate Cortisol replacement. However, obesity occurs more often in the absence of an endocrinopathy. We reviewed 31 patients (10 females, 21 males) with midline intracranial defects (holoprosencephaly, absence of septum pellucidum, absence of corpus callosum, optic nerve hypoplasia) and correlated the morphology of the hypothalamus with body mass index (BMI), as BMI SDS. Endocrinopathies were present in 16 out of the 31 patients. We conclude that there was a trend of increasing mean BMI SDS with increasing hypothalamic abnormality, although this was not statistically significant. surgery for craniopharyngioma, hyperphagia and obesity have been noted, depending in part on tumour characteristics at presentation, as well as the neurosurgical aims 2 . The degree of hypothalamic damage, from both tumour and surgery, has been correlated with the degree of post-operative obesity 2 . Obesity is common in children with midline defects of the brain, due to various endocrine reasons 3 : hypothyroidism, growth hormone (GH) deficiency and inappropriate Cortisol replacement. This study correlates the magnetic resonance imaging (MRI) abnormalities of the hypothalamus in patients with congenital midline intracranial
Journal of Pediatric Endocrinology and Metabolism – de Gruyter
Published: Feb 1, 2004
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