To the Editor,Procalcitonin (PCT) is well established as a biomarker that reflects the presence and severity of local and systemic bacterial infections, i.e. sepsis  and as valuable tool to guide antibiotic treatment ,  allowing to tailor antibiotic treatment and to reduce antibiotic resistance . PCT is widely used as a rule-out test for sepsis and it is frequently requested by primary care doctors facilitating a clinician decision. Several studies have shown that specific treatment should ideally be initiated within 4 h and no later than 8 h after diagnosis , . Hence, the establishment of a point-of-care (POC) for the determination of the PCT could be of great interest reducing the time to diagnosis for patients with suspected sepsis. To date, only Thermo Fisher has developed a POC (called BRAHMS PCT direct) for fast PCT measurement .In recent times, Radiometer launched a POC test for PCT adapted for emergency situations with a low functional sensitivity. Here, we report the analytical performances of the Radiometer AQT90 FLEX® PCT assay (Neuilly-Plaisance, France) and we evaluate the concordance with Elecsys BRAHMS PCT on Cobas8000/e602© (Roche, Meylan, France) and BRAHMS PCT Kryptor Compact Plus© results from central laboratory considered as reference
Clinical Chemistry and Laboratory Medicine (CCLM) – de Gruyter
Published: Jul 26, 2017
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