Adenosine deaminase activity and zinc levels in the serum of patients with diabetes mellitus

Adenosine deaminase activity and zinc levels in the serum of patients with diabetes mellitus Abstract Objective: Adenosine deaminase (ADA) specifically catalyzes the deamination of adenosine which has been proved to play an important role in modulation of insulin action on glucose metabolism. Zinc is an essential micronutrient that is directly involved in the physiology of insulin and may be an important agent to activate the ADA. We aimed to evaluate serum ADA activity, zinc levels and the relationship between these two parameters in diabetes mellitus. Methods: We investigated serum ADA activity and zinc levels in type I (n = 100) and type II diabetes mellitus patients (n = 151). Results: ADA activities of diabetic patients were significantly elevated, whereas zinc levels were significantly lower than those of healthy controls (p < 0.001). Compared with the well-controlled diabetic patient groups (HbA 1c < 7%), the poorly controlled diabetic groups (HbA 1c > 8%) showed significantly increased ADA activity (p < 0.001). In contrast, zinc concentrations in the poorly controlled diabetic groups were not significantly different from those in the well-controlled diabetic patients (p = 0.246). Significant positive correlation was observed between ADA activity and HbA 1c (r = 0.794). There was no correlation between ADA activity and zinc levels (r = 0.043; p > 0.05). Conclusion: Elevated ADA activity in diabetic patients with poor glycemic control may be a useful marker for therapy modulation. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Turkish Journal of Biochemistry de Gruyter

Adenosine deaminase activity and zinc levels in the serum of patients with diabetes mellitus

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Publisher
de Gruyter
Copyright
Copyright © 2016 by the
ISSN
0250-4685
eISSN
1303-829X
DOI
10.1515/tjb-2016-0137
Publisher site
See Article on Publisher Site

Abstract

Abstract Objective: Adenosine deaminase (ADA) specifically catalyzes the deamination of adenosine which has been proved to play an important role in modulation of insulin action on glucose metabolism. Zinc is an essential micronutrient that is directly involved in the physiology of insulin and may be an important agent to activate the ADA. We aimed to evaluate serum ADA activity, zinc levels and the relationship between these two parameters in diabetes mellitus. Methods: We investigated serum ADA activity and zinc levels in type I (n = 100) and type II diabetes mellitus patients (n = 151). Results: ADA activities of diabetic patients were significantly elevated, whereas zinc levels were significantly lower than those of healthy controls (p < 0.001). Compared with the well-controlled diabetic patient groups (HbA 1c < 7%), the poorly controlled diabetic groups (HbA 1c > 8%) showed significantly increased ADA activity (p < 0.001). In contrast, zinc concentrations in the poorly controlled diabetic groups were not significantly different from those in the well-controlled diabetic patients (p = 0.246). Significant positive correlation was observed between ADA activity and HbA 1c (r = 0.794). There was no correlation between ADA activity and zinc levels (r = 0.043; p > 0.05). Conclusion: Elevated ADA activity in diabetic patients with poor glycemic control may be a useful marker for therapy modulation.

Journal

Turkish Journal of Biochemistryde Gruyter

Published: Dec 1, 2016

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