A New Look at the Limits of Detection (L D ), Quantification (L Q ) and Power of Definition (PD)

A New Look at the Limits of Detection (L D ), Quantification (L Q ) and Power of Definition (PD) Gautschi et al.: Limit of detection, limit of quantification, power of definition Eur. J. Clin. Chem. Clin. Biochem. Vol. 31, 1993, pp. 433-440 © 1993 Walter de Gruyter & Co. Berlin · New York By K. Gautschi1, B. Keller2, H. Keller*, P. Pei1 and D. J. Vonderschmitt1 Instituiför Klinische Chemie, Universitätsspital, Zürich, Schweiz Universite Paris 7, UFR de Mathematiques 2, Paris (Received January 22/April 5, 1993) Summary: The relationship between the concentration of the analyte and the imprecision of an analytical method can be displayed by the precision profile in which the coefficient of variation (relative standard deviation) is plotted against the concentration of the analyte. The function of the curve of the profile and its confidence limits can easily be assessed by a computer program developed by W. A. Sadler & M. H. Smith (Clin. Chem. 36 (1990), 1346 -- 1350). For the assessment of limits of detection and of quantification the following procedure is proposed: The lower (and upper) limit of the measuring interval is defined by the point at which an acceptable CV-line intersects the confidence limit. If, in the variance function one sets the concentration to zero, the normal distribution of the random errors http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Clinical Chemistry and Laboratory Medicine de Gruyter

A New Look at the Limits of Detection (L D ), Quantification (L Q ) and Power of Definition (PD)

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Publisher
de Gruyter
Copyright
Copyright © 2009 Walter de Gruyter
ISSN
1434-6621
eISSN
1437-4331
DOI
10.1515/cclm.1993.31.7.433
Publisher site
See Article on Publisher Site

Abstract

Gautschi et al.: Limit of detection, limit of quantification, power of definition Eur. J. Clin. Chem. Clin. Biochem. Vol. 31, 1993, pp. 433-440 © 1993 Walter de Gruyter & Co. Berlin · New York By K. Gautschi1, B. Keller2, H. Keller*, P. Pei1 and D. J. Vonderschmitt1 Instituiför Klinische Chemie, Universitätsspital, Zürich, Schweiz Universite Paris 7, UFR de Mathematiques 2, Paris (Received January 22/April 5, 1993) Summary: The relationship between the concentration of the analyte and the imprecision of an analytical method can be displayed by the precision profile in which the coefficient of variation (relative standard deviation) is plotted against the concentration of the analyte. The function of the curve of the profile and its confidence limits can easily be assessed by a computer program developed by W. A. Sadler & M. H. Smith (Clin. Chem. 36 (1990), 1346 -- 1350). For the assessment of limits of detection and of quantification the following procedure is proposed: The lower (and upper) limit of the measuring interval is defined by the point at which an acceptable CV-line intersects the confidence limit. If, in the variance function one sets the concentration to zero, the normal distribution of the random errors

Journal

Clinical Chemistry and Laboratory Medicinede Gruyter

Published: Jan 1, 1993

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