Genetic Analysis of Children With Cyclic Vomiting Syndrome (CVS) and Migraines
The purpose of this study is to determine if there are genetic variations that can explain a genetic basis for cyclic vomiting syndrome (CVS), various phenotypes of CVS (e.g. menstrual, Sato, calendar-tied) and migraine headaches (e.g. with aura, without aura, hemiplegic migraine). This information will allow physicians to improve care for patients who have been diagnosed with this disease and to provide their parents with more complete information regarding the cause of this disease. This research is being done because many unanswered questions remain regarding children with CVS.
Time Perspective: Prospective
Genetic Analysis of Children With Cyclic Vomiting Syndrome and Migraines
Vomiting Syndrome Migraines
Identify novel genes that contribute to the risk of CVS using genomewide association analysis approach.
Perform genotype-phenotype correlations between genetic profiles and various phenotypes of CVS (e.g. menstrual, Sato, calendar-tied) and migraine headaches (e.g. with aura, without aura, hemiplegic migraine)
Cyclic vomiting syndrome (CVS) may be the most severe recurrent vomiting disorder in - humans. CVS is characterized by a sudden onset of rapid-fire vomiting, usually beginning - in the early morning hours or upon wakening. It has a peak vomiting intensity of every - 5-10 minutes (6-12 emeses) and episodes last between 2 hours and 10 days. These episodes - of acute vomiting occur on average once every 2 to 4 weeks. The child returns to - completely normal health between vomiting episodes. Children are diagnosed based on their - specific vomiting pattern and a lack of positive findings on laboratory testing.
MINIMUM AGE: N/A
MAXIMUM AGE: 21 Years
Children's Hospital of Wisconsin. Milwaukee. Wisconsin. 53226. United States. Recruiting. B Li, MD. 414-266-3690. firstname.lastname@example.org. B Li, MD. Principal Investigator.
July 31, 2008
January 14, 2010