Sensory Neuron , Vol. 3, No. 2, pp. 109– 118 (2000) Ó VSP 2000. Toxic effects of the sh drug acri avine on ampullary electroreceptors of cat sh F. BRETSCHNEIDER, J. W. F. VAN DONGEN, W. J. G. LOOS and R. C. PETERS Laboratory of Comparative Physiology, Padualaan 8, 3584 CH Utrecht, The Netherlands Abstract —The sh anti-ectoparasitedrug acri avine proved to damage ampullary electroreceptoror- gans in the transparent cat sh, Kryptopterus . We tested concentrations of 0.5– 10 mg/ l, and recorded both morphological changes and electrosensitivityin two types of experiments: short-term (2 h) with continuous monitoring and long-term (weeks) with occasional testing of receptor functioning. At the recommended therapeutical concentration(10 mg/ l) and lower, the electrosensitivity is abolished within minutes to 0.5 h. The spontaneous spike rate is affected less. Recovery takes place at the lower concentrations only and even then is only partial (less organs, lower electrosensitivity). Most organs degenerated visibly in 1–3 days. Many receptors degenerated beyond recovery, leaving gaps in the original pattern. Some surviving organs have, after 15 weeks, a far too low electrosensitivity. The acri avine is thought to damage the receptor cells rather than the nerve bres.
Sensory Neuron – Brill
Published: Jan 1, 2000
Keywords: SKIN; ICTALURUS NEBULOSUS; KRYPTOPTERUS BICIRRHIS; TRYPAFLAVINE; SILURIDAE; SENSORY TRANSDUCTION; AMPULLARY ELECTRORECEPTOR
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