Haematologia , Vol. 30, No. 3, pp. 225 – 227 (2000) Ó VSP 2000. Case report Theophylline as a therapy for chronic lymphocytic leukemia: a case report and review of literature SUJIT BASU 1 , ∗ and RITA MITRA (BASU) 2 1 Department of Medical Oncology, Chittaranjan National Cancer Institute, Calcutta, India 2 Department of Pathology, Institute of Post-Graduate Medical Education and Research, Calcutta, India Abstract —We herein, report that theophylline which can induce apoptosis in chronic lymphocytic leukemia (CLL) cells both in vitro and in vivo , also appears to be effective when used clinically to treat an advanced CLL patient. Key words : CLL; theophylline. INTRODUCTION Theophylline, a methylxanthine which has been extensively used for the treat- ment of bronchial asthma acts by inhibiting phosphodiesterase, the enzyme re- sponsible for degradation of cyclic adenosine monophosphate (cAMP) to adeno- sine monophosphate (AMP) thereby accumulating cAMP [1, 2]. This second mes- senger in turn has been found to be involved in the regulation of many genes . Interestingly,there are also reports which suggest that theophylline can induce apop- tosis in lymphocytes from chronic lymphocytic leukemia (CLL) patients indirectly through accumulation of cAMP both in vitro [4, 5] and
Haematologia – Brill
Published: Jan 1, 2000
Keywords: theophylline; CLL
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