Requirements for branched chain amino acids and their interactions in the nematode Caenorhabditis elegans

Requirements for branched chain amino acids and their interactions in the nematode Caenorhabditis... Nematology , 2000, Vol. 2(5), 501-506 Requirements for branched chain amino acids and their interactions in the nematode Caenorhabditis elegans Dalia P ERELMAN and Nancy C. L U * San Jose State University, Department of Nutrition and Food Science, One Washington Square, San Jose, CA 95192-0058,USA Accepted for publication: 14 April 2000 Summary – Branched chain amino acid (BCAA) requirements and their interactions were studied in the nematode Caenorhabditis elegans . Optimal, deŽ ciency and toxic levels affecting nematode population growth were determined for each of the three BCAAs. The optimal range for leucine was 0.72-2.8; for isoleucine, 0.86-1.7; and for valine, 0.51-4.1 mg ml ­ 1 . Leucine at high concentrations was toxic. When isoleucine and valine were both added at high concentrations, they also exerted a marked toxic effect. The interactions of the branched chain amino acids found among vertebrate animals were not observed in C. elegans . Résumé – Les besoins relatifs aux amino-acides en chaîne ramiŽ ée et leurs interactions chez le nématode Caenorhabditis elegans – Les besoins relatifs aux amino-acides en chaîne ramiŽ ée (BCAA) et leurs interactions ont été étudiés chez le nématode Caenorhabditis elegans . Les niveaux optimal, de déŽ cience http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Nematology Brill

Requirements for branched chain amino acids and their interactions in the nematode Caenorhabditis elegans

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Publisher
Brill
Copyright
© 2000 Koninklijke Brill NV, Leiden, The Netherlands
ISSN
1388-5545
eISSN
1568-5411
D.O.I.
10.1163/156854100509411
Publisher site
See Article on Publisher Site

Abstract

Nematology , 2000, Vol. 2(5), 501-506 Requirements for branched chain amino acids and their interactions in the nematode Caenorhabditis elegans Dalia P ERELMAN and Nancy C. L U * San Jose State University, Department of Nutrition and Food Science, One Washington Square, San Jose, CA 95192-0058,USA Accepted for publication: 14 April 2000 Summary – Branched chain amino acid (BCAA) requirements and their interactions were studied in the nematode Caenorhabditis elegans . Optimal, deŽ ciency and toxic levels affecting nematode population growth were determined for each of the three BCAAs. The optimal range for leucine was 0.72-2.8; for isoleucine, 0.86-1.7; and for valine, 0.51-4.1 mg ml ­ 1 . Leucine at high concentrations was toxic. When isoleucine and valine were both added at high concentrations, they also exerted a marked toxic effect. The interactions of the branched chain amino acids found among vertebrate animals were not observed in C. elegans . Résumé – Les besoins relatifs aux amino-acides en chaîne ramiŽ ée et leurs interactions chez le nématode Caenorhabditis elegans – Les besoins relatifs aux amino-acides en chaîne ramiŽ ée (BCAA) et leurs interactions ont été étudiés chez le nématode Caenorhabditis elegans . Les niveaux optimal, de déŽ cience

Journal

NematologyBrill

Published: Jan 1, 2000

Keywords: VALINE; NUTRITION; LEUCINE; ISOLEUCINE

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