ON THE ROLE OF GLIAL CELLS IN DUAL SECRETORY DYNAMICS OF THE CAUDODORSAL CELLS OF L YMNAEA STAGNALIS by E. D. SCHMIDT* and E. W. ROUBOS** (Department of Biology, Vrije Universiteit Amsterdam, P.O. Box 7161, 1007 MC Amsterdam, The Netherlands) SUMMARY The Caudodorsal cells (CDC) of Lymnaea stagnalis are neurons that control egg laying and egg-laying behaviour by releasing various peptides, including the ovulation hor- mone CDCH. Release occurs in a dual fashion, viz. 1. into the haemolymph, from neurohacmal axon terminals in the outer compartment of the cerebral commissure and 2. into the intercellular space of the central nervous system, from nonsynaptic release sites of axon collaterals in the inner compartment of the commissure. Previous studies have shown that neurohaemal CDCH-release is maximal during electrical activity of the CDC (active state) whereas CDCH-release from the collaterals particu- larly occurs during electrical silence (resting and inhibition states). Inner and outer compartment are separated by a continuous sheath of glial cells. Immunoelectron microscopy with an antibody against a synthesized fragment of CDCH (CDCH20-36) including the use of the TAGO-method for the visualization of CDCH-release, shows that in the active state CDCH-immunoreactivity of the intercellular space is much higher (x5)
Netherlands Journal of Zoology (in 2003 continued as Animal Biology) – Brill
Published: Jan 1, 1987
Keywords: glial cells; nonsynaptic release; neurhaemal release; phagocytosis; Lymnaea stagnalis; caudodorsal cells; peptides; blood brain barrier
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