Neurodepressing Hormone (Ndh): Fact or Fiction?

Neurodepressing Hormone (Ndh): Fact or Fiction? REVIEW ARTICLE NEURODEPRESSING HORMONE (NDH): FACT OR FICTION? BY ALBERTO HUBERMAN Instituto Nacional dc la Nutrición "Salvador Zubirán", Department of Biochemistry, Vasco de Quiroga 15, Tlalpan, 14000 Mexico, D.F., Mexico ABSTRACT Extracts of the crustacean eyestalk, and particularly of the sinus gland, produce an inhibition of the spontaneous firing rate of motor and sensitive neurons in two different bioassays. This activity can be ascribed to a molecule of low molecular weight, neutral, non-peptidic, soluble in water and methanol, thermostable, different from GABA but suppressed by picrotoxin. Its nature remains to be elucidated. RÉSUMÉ Des extraits de pédoncule oculaire de Crustacés, et particulièrement de la glande du sinus, produisent une inhibition du taux d'activation spontanée des neurones moteurs et sensitifs dans deux bio-essais différents. Cette activité peut être attribuée à une molécule de faible poids moléculaire, neutre, non peptidique, soluble dans l'eau et le méthanol, thermostable, différente du GABA, mais supprimée par la picrotoxine. Sa nature reste à déterminer. INTRODUCTION Since its inception, the notion of the existence of a neurodepressing activity in the crustacean eyestalk and particularly in the sinus gland, has fired the imagination and stimulated experimentation of numerous physiologists and marine biologists due to its possible http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Crustaceana Brill

Neurodepressing Hormone (Ndh): Fact or Fiction?

Crustaceana , Volume 69 (1): 1 – Jan 1, 1996

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Publisher
Brill
Copyright
© 1996 Koninklijke Brill NV, Leiden, The Netherlands
ISSN
0011-216x
eISSN
1568-5403
D.O.I.
10.1163/156854096X00015
Publisher site
See Article on Publisher Site

Abstract

REVIEW ARTICLE NEURODEPRESSING HORMONE (NDH): FACT OR FICTION? BY ALBERTO HUBERMAN Instituto Nacional dc la Nutrición "Salvador Zubirán", Department of Biochemistry, Vasco de Quiroga 15, Tlalpan, 14000 Mexico, D.F., Mexico ABSTRACT Extracts of the crustacean eyestalk, and particularly of the sinus gland, produce an inhibition of the spontaneous firing rate of motor and sensitive neurons in two different bioassays. This activity can be ascribed to a molecule of low molecular weight, neutral, non-peptidic, soluble in water and methanol, thermostable, different from GABA but suppressed by picrotoxin. Its nature remains to be elucidated. RÉSUMÉ Des extraits de pédoncule oculaire de Crustacés, et particulièrement de la glande du sinus, produisent une inhibition du taux d'activation spontanée des neurones moteurs et sensitifs dans deux bio-essais différents. Cette activité peut être attribuée à une molécule de faible poids moléculaire, neutre, non peptidique, soluble dans l'eau et le méthanol, thermostable, différente du GABA, mais supprimée par la picrotoxine. Sa nature reste à déterminer. INTRODUCTION Since its inception, the notion of the existence of a neurodepressing activity in the crustacean eyestalk and particularly in the sinus gland, has fired the imagination and stimulated experimentation of numerous physiologists and marine biologists due to its possible

Journal

CrustaceanaBrill

Published: Jan 1, 1996

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