INTRODUCTION Peroxiredoxins (Prxs) are a ubiquitous family of antioxidant enzymes that catalyse the reduction of peroxides (Kim et al., 1989). They remove hydrogen peroxide to reduce oxidative stress and to protect the inactivation of multiple cellular enzymes (Rhee et al., 2005). They can also mediate signal transduction by controlling cytokine-induced peroxide levels in mammalian cells (Rhee et al., 2005). In addition to be scavengers and mediators of hydrogen peroxide signalling, Prxs involve not only cellular response to oxidative stress but also a variety of physiological or pathological processes (Jiang et al., 2014). Prxs are essential components in cells to eliminate excessive reactive oxygen species (ROS), such as superoxide anion (O 2− ), hydrogen peroxide (H 2 O 2 ), and hydroxyl radical (OH − ) (Wang et al., 2012). Expression of Prx can be induced when the organisms are faced with oxidative stress caused by H 2 O 2 stimulation, temperature, or virus infection (Kim et al., 2005; Lee et al., 2005; Wang et al., 2012). The mammalian Prx family contains six different isoforms (Prx I-VI), which are classified into four subtypes, i.e., 1-Cys Prx, 2-Cys Prx, type II Prx (Prx II), and Prx Q, according to the
Crustaceana – Brill
Published: Jan 1, 2015
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