Haematologia , Vol. 32, No. 1, pp. 25– 30 (2002) Ó VSP 2002. Also available online - www.vsppub.com Article Evaluation of fractionated total body irradiation and dose rate on cataractogenesis in bone marrow transplantation MURAT BEYZADEOGLU 1 ; ¤ , BAHAR DIRICAN 1 , KAAN OYSUL 1 , FIKRET ARPACI 2 and YUCEL PAK 1 1 Department of Radiation Oncology, Gulhane Military Medical School, 06018 Etlik, Ankara, Turkey 2 Department of Medical Oncology, Gulhane Military Medical School, Turkey Abstract — Purpose : To assess dose rate effect on cataractogenesis in allogeneic or autologous bone marrow transplanted patients conditioned with fractionated total-body irradiation (FTBI). Materials and methods : Between 1987 and 2001, a total of 105 patients have received TBI condi- tioning for Bone Marrow Transplantation (BMT) for hematological malignancies at Gulhane Military Medical School. 12 Gy FTBI was applied in 6 fractions over 3 consecutive days with a Co60 tele- therapy machine. 46 patients who have survived and were followed up after more than one year were evaluated for cataractogenesis in relation to dose rate. Conditioning therapy included only cyclophosphamide (60 mg/ kg/ day for two days) C TBI with no steroid and veno-occlusive disease prophylaxis. Results :
Haematologia – Brill
Published: Jan 1, 2002
Keywords: cataractogenesis; dose rate; bone marrow transplantation; fractionated total body irradiation
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