Sensory Neuron , Vol. 3, No. 2, pp. 119– 125 (2000) Ó VSP 2000. Effects of amiloride and W-7 on the chemoreception of NaCl and KCl in the blow y: implications for the salt quality A. LISCIA ¤ , P. SOLARI and R. CRNJAR Dipartimento di Biologia Sperimentale, Sezione di Fisiologia Generale, Università di Cagliari, Cittadella Universitaria, SS 554, Km 4,5, I-09042 Cagliari, Italy Abstract —The role of amiloride in the labellar responses to various salt stimuli in the blow y Protophormia terraenovae was studied with the aim of ascertaining whether salt reception is mediated by an amiloride-sensitive cation conductance. Results indicate that, unlike the case of NaCl, KCl sensitivity is inhibited by amiloride. W-7 (a calmodulin antagonist, involved in the Ca 2 C cascade) strongly inhibits the chemosensillar response to both NaCl and KCl. Implications of transduction mechanisms for the ‘salt’ and ‘water’ chemoreceptors are discussed. Keywords : ‘Salt’ receptor; ‘water’ receptor; blow ies; amiloride; W-7. 1. INTRODUCTION In previous papers, Liscia et al . (1997, 1998) concluded that, in the blow y Pro- tophormia terraenovae , neither NaCl nor pyranose sugar (sucrose) chemoreception is mediated by amiloride-sensitive receptor sites. This molecule has been reported to reversibly
Sensory Neuron – Brill
Published: Jan 1, 2000
Keywords: 'WATER' RECEPTOR; BLOWFLIES; W-7; AMILORIDE; 'SALT' RECEPTOR
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