Axotomy-induced vacuolation of primary sensory neurons and effect of administered neurotrophic factors: a morphometric, immunocytochemical and ultrastructural study

Axotomy-induced vacuolation of primary sensory neurons and effect of administered neurotrophic... Prim. Sensory Neuron , Vol. 2, No. 2, pp. 111 – 127 (1997) Ó VSP 1997. Axotomy-induced vacuolation of primary sensory neurons and effect of administered neurotrophic factors: a morphometric, immunocytochemical and ultrastructural study M. GROVES, 1 B. GIOMETTO 2 and F. SCARAVILLI 1 , ∗ 1 Department of Neuropathology , Institute of Neurology , Queen Square , London WC1 N 3BG , UK 2 II Neurologic Clinic , University of Padova , Padova , Italy Received 21 August 1996; accepted 10 February 1997 Abstract —L 4 and L 5 dorsal root ganglia from adult Sprague-Dawley rats were examined 2 weeks, and 1, 2, 3, and 6 months after unilateral transection of the sciatic nerve at mid-thigh level. The incidence of neuronal vacuolation was assessed at each time point, using the contralateral ganglia as controls. In addition, immunohistochemistry, neuronal tracing and electron microscopy were performed on the ganglia of rats 1 – 2 months after sciatic transection, a time at which we observed the greatest incidence of vacuolation. The effect of allowing regeneration (after nerve crush) and of administration of the neurotrophic factors nerve growth factor, brain-derived neurotrophic factor, NT3 and ciliary neurotrophic factor upon the incidence of http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Primary Sensory Neuron Brill

Axotomy-induced vacuolation of primary sensory neurons and effect of administered neurotrophic factors: a morphometric, immunocytochemical and ultrastructural study

Primary Sensory Neuron, Volume 2 (2): 111 – Jan 1, 1997

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Publisher
Brill
Copyright
© 1997 Koninklijke Brill NV, Leiden, The Netherlands
ISSN
0929-9637
eISSN
1879-5323
D.O.I.
10.1163/092996397750131919
Publisher site
See Article on Publisher Site

Abstract

Prim. Sensory Neuron , Vol. 2, No. 2, pp. 111 – 127 (1997) Ó VSP 1997. Axotomy-induced vacuolation of primary sensory neurons and effect of administered neurotrophic factors: a morphometric, immunocytochemical and ultrastructural study M. GROVES, 1 B. GIOMETTO 2 and F. SCARAVILLI 1 , ∗ 1 Department of Neuropathology , Institute of Neurology , Queen Square , London WC1 N 3BG , UK 2 II Neurologic Clinic , University of Padova , Padova , Italy Received 21 August 1996; accepted 10 February 1997 Abstract —L 4 and L 5 dorsal root ganglia from adult Sprague-Dawley rats were examined 2 weeks, and 1, 2, 3, and 6 months after unilateral transection of the sciatic nerve at mid-thigh level. The incidence of neuronal vacuolation was assessed at each time point, using the contralateral ganglia as controls. In addition, immunohistochemistry, neuronal tracing and electron microscopy were performed on the ganglia of rats 1 – 2 months after sciatic transection, a time at which we observed the greatest incidence of vacuolation. The effect of allowing regeneration (after nerve crush) and of administration of the neurotrophic factors nerve growth factor, brain-derived neurotrophic factor, NT3 and ciliary neurotrophic factor upon the incidence of

Journal

Primary Sensory NeuronBrill

Published: Jan 1, 1997

Keywords: axotomy; immunohistochemistry; neurotrophic factors; Vacuolation; morphometry

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