Prim. Sensory Neuron , Vol. 2, No. 2, pp. 111 – 127 (1997) Ó VSP 1997. Axotomy-induced vacuolation of primary sensory neurons and effect of administered neurotrophic factors: a morphometric, immunocytochemical and ultrastructural study M. GROVES, 1 B. GIOMETTO 2 and F. SCARAVILLI 1 , ∗ 1 Department of Neuropathology , Institute of Neurology , Queen Square , London WC1 N 3BG , UK 2 II Neurologic Clinic , University of Padova , Padova , Italy Received 21 August 1996; accepted 10 February 1997 Abstract —L 4 and L 5 dorsal root ganglia from adult Sprague-Dawley rats were examined 2 weeks, and 1, 2, 3, and 6 months after unilateral transection of the sciatic nerve at mid-thigh level. The incidence of neuronal vacuolation was assessed at each time point, using the contralateral ganglia as controls. In addition, immunohistochemistry, neuronal tracing and electron microscopy were performed on the ganglia of rats 1 – 2 months after sciatic transection, a time at which we observed the greatest incidence of vacuolation. The effect of allowing regeneration (after nerve crush) and of administration of the neurotrophic factors nerve growth factor, brain-derived neurotrophic factor, NT3 and ciliary neurotrophic factor upon the incidence of
Primary Sensory Neuron – Brill
Published: Jan 1, 1997
Keywords: axotomy; immunohistochemistry; neurotrophic factors; Vacuolation; morphometry
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