Haematologia , Vol. 32, No. 2, pp. 121– 128 (2002) Ó VSP 2002. Also available online - www.vsppub.com Article Association of the platelet glycoprotein Ia C807T /G873A gene polymorphism and thrombosis in Behçet patients GÜRBÜZ POLAT 1 ; ¤ , GÜLÇIN ESKANDARI 1 , TAMER IRFAN KAYA 2 , ÜMIT TÜRSEN 2 , ÖZLEN BAGDATOGLU 1 , GÜLIZ IKIZOGLU 2 and UGUR ATIK 1 1 Mersin University, Medical Faculty, Department of Biochemistry, Mersin, Turkey 2 Mersin University, Medical Faculty, Department of Dermatology, Mersin, Turkey Abstract —Thrombosis is a common complication of Behçet disease and the pathogenic mechanism of thrombotic tendency in Behçet disease is not well known. Several platelet membrane glycoprotein gene polymorphisms have been identi ed as risk factors for thrombosis. This study aimed to evaluate the possible role of the GP Ia C807T/ G873A polymorphism as a risk factor for thrombosis in Behçet disease. We determined the prevalence of platelet glycoprotein Ia C807T/G873A gene polymorphism in Behçet patients. Genomic DNA was obtained from 20 patients with Behçet disease and 61 controls. All individuals were of Turkish ancestry and were genotyped for the GP Ia C807T/G873A polymorphism with real-time PCR method by LightCycler system. The 807 CC,
Haematologia – Brill
Published: Jan 1, 2002
Keywords: BEHCET'S DISEASE; THROMBUS; PLATELET; GLYCOPROTEIN; POLYMORPHISM
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