Haematologia , Vol. 30, No. 3, pp. 229 – 234 (2000) Ó VSP 2000. Case report Acute Myelomonocytic Leukaemia with Pseudo-Chediak-Higashi inclusions in leukaemic blasts report of an unusual case K. GHOSH 1 , ∗ , † , U. KHANDURI 1 , D. HIWASE 1 , S. VENUGOPAL 2 and D. MUIRHEAD 3 1 Department of Haematology, Sultan Qaboos University, Muscat, Sultanate of Oman 2 Department of Laboratory, Al-Nadha Hospital, Muscat, Sultanate of Oman 3 Division of Electron Microscopy, Sultan Qaboos University Hospital, Muscat, Sultanate of Oman Abstract —Giant inclusions in the blast cells resembling that of Chediak-Higashi syndrome have been reported only in a handful of cases with acute leukaemia. There is a paucity of data on the ultrastructural appearance of such unique light microscopic findings. As many of such patients were reported in late seventies and early eighties [1 – 4] the outcome of treatment using present day multiple induction / consolidation regimens in such patients has also been rarely reported due to the rarity of such patients. We report here on a patient with acute myeloid leukaemia showing pseudo-Chediak-Higashi inclusions in leukaemic blasts with unusual ultrastructural morphology. Key words : Pseudo-Chediak-Higashi Inclusions; ultrastructure; natural history;
Haematologia – Brill
Published: Jan 1, 2000
Keywords: ultrastructure; Pseudo-Chediak-Higashi Inclusions; acute leukemia; natural history
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